- Gene Overview
- Interaction Network
- Sequence Verification
ERVFRD-1, endogenous retrovirus group FRD member 1, envelope
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Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
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Gene Synonyms (ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, syncytin-2, HERV-FRD provirus ancestral Env polyprotein, HERV-FRD_6p24.1 provirus ancestral Env polyprotein, endogenous retrovirus group FRD member 1, envelope polyprotein, syncytin 2,)
- NCBI Gene ID:
405754
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>P60508
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
endogenous retrovirus group FRD member 1, envelope interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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