ADRB2, adrenoceptor beta 2

ADRB2, adrenoceptor beta 2

• This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

• Gene Synonyms (ADRB2R, ADRBR, B2AR, BAR, BETA2AR, beta-2 adrenergic receptor, adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, beta-2 adrenoceptor, beta-2 adrenoreceptor, catecholamine receptor,)
• NCBI Gene ID: 154
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07550
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adrenoceptor beta 2 interacts with:

• 5-hydroxytryptamine receptor 4
  adhesion G protein-coupled receptor G1
  ADP ribosylation factor 4
  adrenoceptor beta 2
  adrenoceptor beta 3
  A-kinase anchoring protein 12
  A-kinase anchoring protein 5
  aldehyde dehydrogenase 18 family member A1
  aldolase, fructose-bisphosphate A
  apoptosis inducing factor mitochondria associated 1
  arrestin 3
  arrestin beta 1
  arrestin beta 2
  arrestin domain containing 1
  arrestin domain containing 3
  arrestin domain containing 4
  ATP synthase F1 subunit alpha
  ATP synthase F1 subunit beta
  ATP synthase F1 subunit gamma
  ATP synthase peripheral stalk subunit OSCP
  ATPase Na+/K+ transporting subunit alpha 1
  ATPase Na+/K+ transporting subunit beta 3
  ATPase plasma membrane Ca2+ transporting 4
  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  autocrine motility factor receptor
  calmegin
  calmodulin 1
  calmodulin 2
  calmodulin 3
  calnexin
  calpain small subunit 1
  calponin 1
  caveolin 3
  CD4 molecule
  CD68 molecule
  CD81 molecule
  CD9 molecule
  CEA cell adhesion molecule 1
  cholecystokinin B receptor
  clathrin heavy chain
  complement C1q binding protein
  C-terminal Src kinase
  cullin 2
  cyclin and CBS domain divalent metal cation transport mediator 3
  defender against cell death 1
  desmoglein 2
  dihydrolipoamide S-acetyltransferase
  DnaJ heat shock protein family (Hsp40) member B11
  dopamine receptor D4
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  electron transfer flavoprotein subunit beta
  elongin C
  ER lipid raft associated 2
  erb-b2 receptor tyrosine kinase 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 beta 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation elongation factor 1 gamma
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 2B subunit alpha
  eukaryotic translation initiation factor 4A1
  family with sequence similarity 162 member A
  filamin A
  FKBP prolyl isomerase 8
  G elongation factor mitochondrial 1
  G protein nucleolar 3 like
  G protein subunit alpha 11
  G protein subunit alpha 14
  G protein subunit alpha 15
  G protein subunit alpha i1
  G protein subunit alpha i2
  G protein subunit alpha i3
  G protein subunit alpha transducin 2
  G protein subunit beta 1
  G protein subunit beta 2
  G protein subunit beta 4
  G protein subunit gamma 12
  G protein subunit gamma 2
  G protein-coupled receptor 37
  G protein-coupled receptor associated sorting protein 1
  G protein-coupled receptor class C group 5 member B
  G protein-coupled receptor kinase 1
  G protein-coupled receptor kinase 2
  G protein-coupled receptor kinase 3
  G protein-coupled receptor kinase 4
  G protein-coupled receptor kinase 5
  G protein-coupled receptor kinase 6
  glutamate ionotropic receptor AMPA type subunit 3
  glutaryl-CoA dehydrogenase
  glyceraldehyde-3-phosphate dehydrogenase
  GNAS complex locus
  growth factor receptor bound protein 2
  guanosine monophosphate reductase 2
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein U
  histone deacetylase 6
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  hydroxysteroid 17-beta dehydrogenase 12
  hydroxysteroid 17-beta dehydrogenase 4
  hydroxysteroid dehydrogenase like 2
  ilvB acetolactate synthase like
  inner membrane mitochondrial protein
  insulin receptor
  interleukin 1 beta
  interleukin 6 receptor
  isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
  isocitrate dehydrogenase (NADP(+)) 2
  itchy E3 ubiquitin protein ligase
  JNK1/MAPK8 associated membrane protein
  karyopherin subunit beta 1
  keratin 1
  keratin 10
  keratin 2
  keratin 5
  keratin 9
  lamin B1
  leucine rich pentatricopeptide repeat containing
  lon peptidase 1, mitochondrial
  major histocompatibility complex, class I, B
  major histocompatibility complex, class I, C
  MDM2 proto-oncogene
  melanoma cell adhesion molecule
  membrane associated ring-CH-type finger 2
  methylcrotonoyl-CoA carboxylase 2
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  microtubule associated protein 1 light chain 3 beta
  mitochondrial ribosomal protein L12
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase 8 interacting protein 2
  myosin light chain kinase 2
  NADH:ubiquinone oxidoreductase core subunit S2
  NADH:ubiquinone oxidoreductase core subunit S3
  NADH:ubiquinone oxidoreductase core subunit V1
  NADH:ubiquinone oxidoreductase subunit A5
  NDUFA4 mitochondrial complex associated
  NEDD4 E3 ubiquitin protein ligase
  N-ethylmaleimide sensitive factor, vesicle fusing ATPase
  nitric oxide synthase 1
  NPL4 homolog, ubiquitin recognition factor
  nucleoporin 155
  nucleoporin 210
  nucleoporin 93
  opioid receptor delta 1
  ornithine aminotransferase
  paraoxonase 2
  phospholipase A2 group IID
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  potassium channel tetramerization domain containing 13
  potassium inwardly rectifying channel subfamily J member 3
  potassium inwardly rectifying channel subfamily J member 5
  potassium inwardly rectifying channel subfamily J member 6
  potassium inwardly rectifying channel subfamily J member 9
  potassium voltage-gated channel subfamily E regulatory subunit 1
  progesterone receptor membrane component 1
  prohibitin
  prohibitin 2
  prostaglandin E receptor 1
  proteasome 26S subunit, non-ATPase 2
  protein disulfide isomerase family A member 6
  protein kinase C delta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 3 catalytic subunit alpha
  pyruvate carboxylase
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate dehydrogenase E1 subunit beta
  RAB18, member RAS oncogene family
  RAB27A, member RAS oncogene family
  RAB3A, member RAS oncogene family
  RAN binding protein 2
  RAN, member RAS oncogene family
  RAP2C, member of RAS oncogene family
  ras homolog family member D
  receptor for activated C kinase 1
  regulator of G protein signaling 10
  regulator of G protein signaling 11
  regulator of G protein signaling 17
  regulator of G protein signaling 2
  regulator of G protein signaling 20
  regulator of G protein signaling 5
  regulator of G protein signaling 8
  regulator of G protein signaling 9
  REL proto-oncogene, NF-kB subunit
  Rho GDP dissociation inhibitor alpha
  Rho GTPase activating protein 5
  ribophorin I
  ribophorin II
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S5
  ring finger protein 41
  ring finger protein 5
  SEC22 homolog B, vesicle trafficking protein
  SEC61 translocon subunit alpha 1
  serine hydroxymethyltransferase 2
  serine palmitoyltransferase long chain base subunit 1
  serpin family H member 1
  signal sequence receptor subunit 4
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 4
  SLC9A3 regulator 1
  SLC9A3 regulator 2
  solute carrier family 1 member 5
  solute carrier family 25 member 10
  solute carrier family 25 member 11
  solute carrier family 25 member 13
  solute carrier family 25 member 3
  solute carrier family 25 member 5
  solute carrier family 25 member 6
  solute carrier family 39 member 14
  solute carrier family 52 member 2
  SRA stem-loop interacting RNA binding protein
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRP receptor subunit beta
  stomatin
  synaptic vesicle glycoprotein 2A
  synaptojanin 2 binding protein
  synuclein gamma
  TAR DNA binding protein
  thioredoxin related transmembrane protein 1
  thyroid stimulating hormone receptor
  titin
  TNF receptor associated factor 1
  transcription factor AP-2 alpha
  transferrin receptor
  translocase of inner mitochondrial membrane 50
  translocase of outer mitochondrial membrane 70
  transmembrane 9 superfamily member 3
  transmembrane and ubiquitin like domain containing 1
  transmembrane protein 259
  transmembrane protein 33
  Tu translation elongation factor, mitochondrial
  tubulin beta 2A class IIa
  tubulin beta class I
  tumor susceptibility 101
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin B
  ubiquitin C
  ubiquitin C-terminal hydrolase L1
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 33
  UBX domain protein 8
  valosin containing protein
  VAMP associated protein A
  vascular endothelial growth factor B
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  von Hippel-Lindau tumor suppressor
  WNK lysine deficient protein kinase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.