AMFR, autocrine motility factor receptor

AMFR, autocrine motility factor receptor

• This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase AMFR, RING finger protein 45, RING-type E3 ubiquitin transferase AMFR, GP78, RNF45,)
• NCBI Gene ID: 267
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6R5
  UNIPROT ID#>>Q9UKV5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

autocrine motility factor receptor interacts with:

• 3-hydroxy-3-methylglutaryl-CoA reductase
  5-hydroxytryptamine receptor 3E
  agrin
  apoptosis inducing factor mitochondria associated 1
  ataxin 3
  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
  AUP1 lipid droplet regulating VLDL assembly factor
  autocrine motility factor receptor
  autophagy related 9A
  BAG cochaperone 6
  BRI3 binding protein
  calmodulin 1
  calnexin
  catenin beta 1
  CD3d molecule
  CD82 molecule
  cell death inducing DFFA like effector c
  CF transmembrane conductance regulator
  chromosome segregation 1 like
  coiled-coil domain containing 47
  collapsin response mediator protein 1
  cytochrome P450 family 2 subfamily E member 1
  cytochrome P450 family 3 subfamily A member 4
  derlin 1
  derlin 2
  derlin 3
  diacylglycerol O-acyltransferase 2
  dihydrofolate reductase
  dual specificity phosphatase 1
  ELAV like RNA binding protein 1
  ER lipid raft associated 1
  ER lipid raft associated 2
  eukaryotic translation elongation factor 1 alpha 1
  family with sequence similarity 189 member B
  Fas associated factor 1
  Fas associated factor family member 2
  glucose-6-phosphate isomerase
  glycine receptor alpha 2
  guided entry of tail-anchored proteins factor 4
  HCLS1 associated protein X-1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 5
  heat shock protein family D (Hsp60) member 1
  homocysteine inducible ER protein with ubiquitin like domain 1
  huntingtin
  hydroxysteroid 17-beta dehydrogenase 3
  inositol 1,4,5-trisphosphate receptor type 1
  insulin induced gene 1
  insulin induced gene 2
  karyopherin subunit beta 1
  limb development membrane protein 1 like
  lunapark, ER junction formation factor
  mahogunin ring finger 1
  mediator of DNA damage checkpoint 1
  mitochondrial antiviral signaling protein
  myosin heavy chain 10
  myosin heavy chain 9
  neurotrophic receptor tyrosine kinase 1
  NPL4 homolog, ubiquitin recognition factor
  OS9 endoplasmic reticulum lectin
  oxysterol binding protein like 8
  peripheral myelin protein 22
  potassium voltage-gated channel subfamily C member 4
  prion protein
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 6
  proteasome activator subunit 4
  protein disulfide isomerase family A member 2
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type H
  protein tyrosine phosphatase receptor type M
  PTEN induced kinase 1
  ras homolog family member T1
  ribosomal protein L5
  ring finger protein 4
  ring finger protein 5
  SEC61 translocon subunit beta
  SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
  selenoprotein S
  small VCP interacting protein
  solute carrier family 13 member 2
  solute carrier family 15 member 3
  solute carrier family 17 member 2
  solute carrier family 45 member 2
  SRP receptor subunit beta
  sterol O-acyltransferase 2
  store-operated calcium entry associated regulatory factor
  superoxide dismutase 1
  synoviolin 1
  target of myb1 like 1 membrane trafficking protein
  t-complex 1
  translocase of inner mitochondrial membrane 50
  transmembrane and ubiquitin like domain containing 1
  transmembrane phosphatase with tensin homology
  transmembrane protein 41B
  tripartite motif containing 25
  tripartite motif containing 28
  UBA domain containing 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 G1
  ubiquitin conjugating enzyme E2 G2
  ubiquitin conjugating enzyme E2 K
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 T
  ubiquitin conjugating enzyme E2 W
  ubiquitin like 4A
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 34
  ubiquitin-conjugating enzyme E2G 2
  UBX domain protein 1
  UBX domain protein 4
  UBX domain protein 7
  valosin containing protein
  WD repeat domain 20
  YOD1 deubiquitinase
  zinc and ring finger 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.