CALM1, calmodulin 1

CALM1, calmodulin 1

• This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]

• Gene Synonyms (calmodulin-1, Calmodulin-2, Calmodulin-3, calmodulin 1 (phosphorylase kinase, delta), phosphorylase kinase subunit delta, phosphorylase kinase, delta subunit, prepro-calmodulin 1, CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, caM,)
• NCBI Gene ID: 801
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P0DP25
  UNIPROT ID#>>P0DP24
  UNIPROT ID#>>P0DP23
  UNIPROT ID#>>B4DJ51
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

calmodulin 1 interacts with:

• 2',3'-cyclic nucleotide 3' phosphodiesterase
  5-hydroxytryptamine receptor 2C
  5'-nucleotidase, cytosolic II
  AAR2 splicing factor
  actin related protein 2/3 complex, subunit 5-like
  actin, beta-like 2
  acyl-CoA synthetase bubblegum family member 1
  adaptor protein complex AP-1, beta 1 subunit
  adaptor-related protein complex 2, beta 1 subunit
  adducin 1 (alpha)
  adducin 2 (beta)
  adhesion G protein-coupled receptor B1
  A-kinase anchoring protein 5
  A-kinase anchoring protein 6
  A-kinase anchoring protein 9
  amphiphysin
  angiotensin I converting enzyme 2
  anillin actin binding protein
  annexin A2
  apoptosis inhibitor 5
  ARFGEF family member 3
  armadillo repeat containing 1
  ATPase, Ca++ transporting, plasma membrane 1
  ATPase, Ca++ transporting, plasma membrane 3
  ATPase, Ca++ transporting, plasma membrane 4
  aurora kinase B
  baculoviral IAP repeat-containing 6
  brain abundant, membrane attached signal protein 1
  brain glycogen phosphorylase
  breast carcinoma amplified sequence 1
  bridging integrator 1
  bromodomain and WD repeat domain containing 1
  calcineurin binding protein 1
  calcium/calmodulin dependent protein kinase I
  calcium/calmodulin dependent protein kinase II gamma
  calcium/calmodulin dependent protein kinase kinase 1
  calcium/calmodulin dependent protein kinase kinase 2
  calcium/calmodulin-dependent protein kinase I
  calcium/calmodulin-dependent protein kinase ID
  calcium/calmodulin-dependent protein kinase II alpha
  calcium/calmodulin-dependent protein kinase II, beta
  calcium/calmodulin-dependent protein kinase II, delta
  calmodulin 1
  calmodulin binding transcription activator 2
  calmodulin-like 3
  calponin 1
  CaM kinase-like vesicle-associated
  CAP-Gly domain containing linker protein 1
  capping protein (actin filament) muscle Z-line, alpha 2
  capping protein (actin filament) muscle Z-line, beta
  capping protein inhibiting regulator of actin like
  casein kinase 2 alpha 1
  casein kinase 2 alpha 2
  casein kinase 2 beta
  caspase 8 associated protein 2
  catenin beta 1
  Cbl proto-oncogene
  cell division cycle 37 like 1
  cell division cycle 5 like
  cell division cycle 5-like (S. pombe)
  centrin 1
  centriolar coiled-coil protein 110
  centrosomal protein 290
  centrosomal protein 97
  CF transmembrane conductance regulator
  chromosome 11 open reading frame 65
  chromosome 4 open reading frame 3
  clathrin interactor 1
  clathrin light chain B
  clathrin, light polypeptide (Lcb)
  CLIP associating protein 2
  coiled-coil domain containing 14
  coronin, actin binding protein 1C
  corticotropin releasing hormone receptor 1
  creatine kinase, mitochondrial 1B
  cullin 1
  cullin 3
  cullin 4B
  cyclic nucleotide gated channel subunit alpha 2
  cyclin A2
  cyclin D2
  cyclin dependent kinase 9
  cyclin E1
  cyclin G associated kinase
  CYLD lysine 63 deubiquitinase
  cytochrome c oxidase subunit 6C
  cytoplasmic FMR1 interacting protein 1
  cytoskeleton associated protein 5
  DEAD box helicase 17
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 5
  death associated protein kinase 1
  dedicator of cytokinesis 11
  dedicator of cytokinesis 3
  defective in cullin neddylation 1 domain containing 1
  DExD-box helicase 21
  DExD-box helicase 39B
  dihydrolipoamide S-succinyltransferase
  dihydropyrimidinase-like 2
  dimethylarginine dimethylaminohydrolase 1
  DIRAS family, GTP-binding RAS-like 2
  DISC1 scaffold protein
  discs large MAGUK scaffold protein 3
  Dmx like 1
  DNA damage inducible transcript 4 like
  DnaJ heat shock protein family (Hsp40) member C13
  dopamine receptor D2
  doublecortin-like kinase 1
  drebrin 1
  dynactin subunit 2
  dynamin 1 like
  dynein axonemal assembly factor 2
  dynein axonemal assembly factor 4
  dynein cytoplasmic 1 heavy chain 1
  dynein cytoplasmic 1 intermediate chain 1
  dynein cytoplasmic 1 light intermediate chain 1
  dynein light chain roadblock-type 1
  dynein light chain roadblock-type 2
  dynein, cytoplasmic 1 light intermediate chain 2
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  endothelial differentiation related factor 1
  epidermal growth factor receptor
  erb-b2 receptor tyrosine kinase 2
  erythrocyte membrane protein band 4.1 like 2
  erythrocyte membrane protein band 4.1 like 3
  estrogen receptor 1
  estrogen receptor 2
  estrogen related receptor gamma
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 5B
  EWS RNA binding protein 1
  far upstream element (FUSE) binding protein 1
  F-box protein 9
  FER tyrosine kinase
  ferrochelatase
  filamin A
  filamin, beta
  FKBP prolyl isomerase 3
  FKBP prolyl isomerase 4
  FKBP prolyl isomerase 8
  formin binding protein 1
  G protein-coupled receptor kinase 1
  G protein-coupled receptor kinase 4
  G protein-coupled receptor kinase 5
  gap junction protein beta 1
  general transcription factor IIi
  GID complex subunit 8 homolog
  glucagon like peptide 1 receptor
  glucagon like peptide 2 receptor
  glutamate decarboxylase-like 1
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate metabotropic receptor 3
  glutamate metabotropic receptor 4
  glutamate metabotropic receptor 5
  glutamate metabotropic receptor 7
  glutamate-cysteine ligase modifier subunit
  glycolipid transfer protein
  glycoprotein Ib platelet subunit alpha
  glycoprotein V platelet
  glycoprotein VI platelet
  GNAS complex locus
  goosecoid homeobox 2
  growth associated protein 43
  growth factor receptor bound protein 7
  GTP binding protein overexpressed in skeletal muscle
  H2A.X variant histone
  H4 clustered histone 1
  heat shock protein 12A
  heat shock protein 90 alpha (cytosolic), class B member 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 4
  hook microtubule tethering protein 3
  huntingtin
  huntingtin interacting protein K
  hyaluronan mediated motility receptor
  inner membrane mitochondrial protein
  inositol 1,4,5-trisphosphate receptor 1
  inositol 1,4,5-trisphosphate receptor type 1
  inositol-trisphosphate 3-kinase A
  inositol-trisphosphate 3-kinase B
  insulin receptor
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 6
  IQ motif containing B1
  IQ motif containing E
  IQ motif containing G
  IQ motif containing GTPase activating protein 1
  IQ motif containing GTPase activating protein 2
  IQ motif containing GTPase activating protein 3
  IQ motif containing N
  Janus kinase 2
  Josephin domain containing 1
  junction plakoglobin
  kinesin family member 1B
  kinesin family member 21A
  kinesin family member 21B
  KRAS proto-oncogene, GTPase
  lactamase beta
  lactotransferrin
  leucine rich repeat kinase 2
  leucine zipper protein 4
  LIM domain 7
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  lin-7 homolog B (C. elegans)
  lin-7 homolog C (C. elegans)
  lon peptidase 1, mitochondrial
  LUC7 like
  lymphocyte antigen 96
  lysine demethylase 5C
  lysosomal trafficking regulator
  lysosomal-associated protein transmembrane 5
  MAGE family member A3
  mahogunin ring finger 1
  major intrinsic protein of lens fiber
  malignant fibrous histiocytoma amplified sequence 1
  MAP3K12 binding inhibitory protein 1
  matrin 3
  matrin 3
  methionine adenosyltransferase II, beta
  methionyl aminopeptidase 2
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
  microtubule associated protein RP/EB family member 1
  microtubule associated protein tau
  microtubule-associated protein 2
  microtubule-associated protein 6
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 14
  MOB family member 4, phocein
  mortality factor 4 like 1
  Mov10 RISC complex RNA helicase
  MYC binding protein 2
  MYC proto-oncogene, bHLH transcription factor
  myelin basic protein
  myogenic differentiation 1
  myogenic factor 5
  myogenic factor 6
  myogenin
  myosin binding protein C1
  myosin heavy chain 9
  myosin IC
  myosin IC
  myosin IXB
  myosin light chain 6
  myosin light chain 6B
  myosin light chain kinase
  myosin light chain kinase 2
  myosin VA
  myosin VIIA
  myosin X
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  myotubularin related protein 1
  myristoylated alanine rich protein kinase C substrate
  NBR1 autophagy cargo receptor
  NCK-associated protein 1
  nebulin
  N-ethylmaleimide sensitive fusion protein attachment protein alpha
  N-ethylmaleimide sensitive fusion protein attachment protein beta
  neurofibromin 1
  neurogranin
  neuronal differentiation 1
  neuronal guanine nucleotide exchange factor
  nexilin F-actin binding protein
  ninein
  nipsnap homolog 1
  nipsnap homolog 2
  nitric oxide synthase 1, neuronal
  nitric oxide synthase 2
  nitric oxide synthase 3
  NMDA receptor synaptonuclear signaling and neuronal migration factor
  nuclear receptor subfamily 3 group C member 1
  nuclear RNA export factor 1
  nucleolar protein 7
  nudC nuclear distribution protein
  obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
  oligodendrocytic myelin paranodal and inner loop protein
  opioid receptor mu 1
  optineurin
  parathyroid hormone 2 receptor
  PDZ and LIM domain 7
  peptidylglycine alpha-amidating monooxygenase
  peptidylprolyl isomerase like 2
  pericentrin
  peroxiredoxin 1
  PHD finger protein 20-like 1
  phosphatase and actin regulator 4
  phosphatase and tensin homolog
  phosphatidylinositol 3-kinase catalytic subunit type 3
  phosphatidylinositol 4-kinase alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphodiesterase 1A
  phosphodiesterase 1A, calmodulin-dependent
  phosphodiesterase 1B, Ca2+-calmodulin dependent
  phosphoenolpyruvate carboxykinase 1
  phosphofructokinase, muscle
  phosphofructokinase, platelet
  phosphofurin acidic cluster sorting protein 1
  phosphoinositide kinase, FYVE type zinc finger containing
  phospholipase A2 group VI
  phospholipase C delta 1
  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  phosphorylase kinase beta
  phosphorylase kinase catalytic subunit gamma 1
  phosphorylase kinase regulatory subunit beta
  PIH1 domain containing 1
  platelet activating factor receptor
  plexin A1
  POC5 centriolar protein
  poly(A) specific ribonuclease subunit PAN2
  potassium calcium-activated channel subfamily N member 1
  potassium calcium-activated channel subfamily N member 2
  potassium calcium-activated channel subfamily N member 3
  potassium calcium-activated channel subfamily N member 4
  potassium voltage-gated channel subfamily B member 1
  potassium voltage-gated channel subfamily H member 1
  potassium voltage-gated channel subfamily Q member 2
  potassium voltage-gated channel subfamily Q member 3
  potassium voltage-gated channel subfamily Q member 5
  programmed cell death 7
  proprotein convertase subtilisin/kexin type 1 inhibitor
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 2
  protein kinase C, alpha
  protein kinase, cAMP dependent regulatory, type II beta
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 3, catalytic subunit, alpha isoform
  protein phosphatase 3, catalytic subunit, beta isoform
  protein phosphatase with EF-hand domain 1
  protein phosphatase with EF-hand domain 2
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase, receptor type, E
  protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
  pumilio RNA binding family member 3
  Purkinje cell protein 4
  pyruvate dehydrogenase E1 subunit alpha 1
  RAB10, member RAS oncogene family
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  RAB15, member RAS oncogene family
  RAB33B, member RAS oncogene family
  RAB37, member RAS oncogene family
  RAB3A, member RAS oncogene family
  RAB3B, member RAS oncogene family
  RAB3B, member RAS oncogene family
  RAB3D, member RAS oncogene family
  RAB6B, member RAS oncogene family
  RAB8B, member RAS oncogene family
  rabphilin 3A
  Rac family small GTPase 1
  RAD18 E3 ubiquitin protein ligase
  RAD23 homolog B, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  radixin
  Raf-1 proto-oncogene, serine/threonine kinase
  RAN binding protein 2
  Rap1 GTPase-activating protein
  RAS like proto-oncogene A
  RAS like proto-oncogene B
  Ras like without CAAX 2
  regulator of G protein signaling 10
  regulator of G protein signaling 2
  regulator of G protein signaling 4
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  reticulon 3
  reticulon 4
  retinoid X receptor alpha
  retinoschisin 1
  Rho GTPase activating protein 44
  Rho guanine nucleotide exchange factor 7
  ribosomal protein L13a
  ribosomal protein L22
  ribosomal protein S14
  ribosomal protein S15a
  ribosomal protein S20
  ribosomal protein S4 Y-linked 1
  ribosomal protein S8
  ring finger and CHY zinc finger domain containing 1
  ring finger protein 2
  RNA polymerase II subunit B
  RNA transcription, translation and transport factor
  rogdi homolog
  RRAD, Ras related glycolysis inhibitor and calcium channel regulator
  ryanodine receptor 1
  ryanodine receptor 2
  S100 calcium binding protein B
  SAFB like transcription modulator
  SEC61 translocon subunit alpha 1
  secreted phosphoprotein 1
  secretin receptor
  septin 11
  septin 3
  septin 4
  septin 5
  septin 6
  septin 8
  sequestosome 1
  serine and arginine rich splicing factor 5
  serine/threonine kinase 38
  seryl-aminoacyl-tRNA synthetase
  SET binding factor 1
  SET binding factor 2
  SET nuclear proto-oncogene
  SH3 domain containing GRB2 like 1, endophilin A2
  SH3 domain containing GRB2 like 2, endophilin A1
  SH3-domain GRB2-like 1
  SH3-domain GRB2-like 2
  signal recognition particle 14
  sirtuin 2
  Sjogren syndrome antigen B
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein polypeptide B2
  small nuclear ribonucleoprotein U1 subunit 70
  SMC5-SMC6 complex localization factor 2
  sodium channel and clathrin linker 1
  sodium voltage-gated channel alpha subunit 4
  sodium voltage-gated channel alpha subunit 5
  solute carrier family 9 member A1
  sorting nexin 6
  Sp1 transcription factor
  spectrin alpha, non-erythrocytic 1
  spectrin beta, non-erythrocytic 1
  spectrin beta, non-erythrocytic 4
  spectrin repeat containing nuclear envelope protein 2
  spermatogenesis associated 17
  S-phase cyclin A associated protein in the ER
  spleen associated tyrosine kinase
  splicing factor 3b subunit 1
  stomatin
  striatin
  striatin 3
  striatin 4
  striatin, calmodulin binding protein
  striatin, calmodulin binding protein 3
  stromal antigen 1
  stromal interaction molecule 2
  supervillin
  synapsin I
  synapsin II
  synaptic vesicle glycoprotein 2 a
  synaptotagmin 1
  synaptotagmin I
  synaptotagmin II
  synaptotagmin V
  syndecan binding protein
  syntaxin 8
  syntaxin binding protein 1
  syntrophin alpha 1
  synuclein alpha
  TBC1 domain family member 1
  TBC1 domain family member 4
  T-box transcription factor 3
  testis development related protein
  thimet oligopeptidase 1
  thymoma viral proto-oncogene 1
  titin
  transcription factor 3
  transcription factor 4
  transcription factor CP2
  transglutaminase 2
  transient receptor potential cation channel subfamily C member 3
  transient receptor potential cation channel subfamily V member 1
  transient receptor potential cation channel subfamily V member 4
  transient receptor potential cation channel subfamily V member 6
  translocase of outer mitochondrial membrane 34
  translocated promoter region, nuclear basket protein
  triadin
  tripartite motif containing 13
  tripartite motif-containing 46
  tropomodulin 3
  troponin I2, fast skeletal type
  TSC complex subunit 2
  tubulin, beta 4A class IVA
  tumor necrosis factor
  tumor protein D52
  tumor protein D52-like 2
  tumor protein, translationally-controlled 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  U2 small nuclear RNA auxiliary factor 2
  ubiquinol-cytochrome c reductase binding protein
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 16
  ubiquitin specific peptidase 20
  ubiquitin-conjugating enzyme E2 variant 1
  ubiquitin-conjugating enzyme E2 variant 2
  unk zinc finger
  utrophin
  Vac14 homolog (S. cerevisiae)
  vacuolar protein sorting 4B
  vasoactive intestinal peptide receptor 1
  vesicle amine transport 1
  vesicle amine transport protein 1 like
  vesicle associated membrane protein 2
  WD repeat domain 37
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 4
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger and BTB domain containing 24
  zinc finger protein 280A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.