DRD4, dopamine receptor D4

DRD4, dopamine receptor D4

• This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

• Gene Synonyms (D4DR, D(4) dopamine receptor, D(2C) dopamine receptor, dopamine D4 receptor, seven transmembrane helix receptor,)
• NCBI Gene ID: 1815
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21917
  UNIPROT ID#>>A0A0G2JM26
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dopamine receptor D4 interacts with:

• chloride intracellular channel 6
  cullin 3
  G protein subunit alpha i1
  growth factor receptor bound protein 2
  kelch like family member 12
  NCK adaptor protein 1
  potassium inwardly rectifying channel subfamily J member 3
  potassium inwardly rectifying channel subfamily J member 5
  potassium inwardly rectifying channel subfamily J member 9
  SRC proto-oncogene, non-receptor tyrosine kinase
  STIP1 homology and U-box containing protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.