ARHGDIA, Rho GDP dissociation inhibitor alpha

ARHGDIA, Rho GDP dissociation inhibitor alpha

• This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• Gene Synonyms (rho GDP-dissociation inhibitor 1, GDP-dissociation inhibitor, aplysia RAS-related 1, Rho GDP dissociation inhibitor (GDI) alpha, epididymis secretory sperm binding protein Li 47e, GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1,)
• NCBI Gene ID: 396
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52565
  UNIPROT ID#>>J3QQX2
  UNIPROT ID#>>V9HWE8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GDP dissociation inhibitor alpha interacts with:

• 3-hydroxyanthranilate 3,4-dioxygenase
  agrin
  AHNAK nucleoprotein
  aminopeptidase like 1
  ankyrin repeat domain 13A
  anterior gradient 2, protein disulphide isomerase family member
  argininosuccinate synthase 1
  ataxin 3
  BCL2 antagonist/killer 1
  BH3 interacting domain death agonist
  caspase 10
  caspase 3
  caspase 7
  caspase 8
  cell division cycle 42
  chromobox 5
  coactosin like F-actin binding protein 1
  coiled-coil domain containing 8
  COMM domain containing 4
  C-terminal Src kinase
  cullin 3
  cullin 7
  cyclin dependent kinase 2
  cyclin dependent kinase inhibitor 1B
  deoxyuridine triphosphatase
  DExH-box helicase 9
  E1A binding protein p300
  enolase 2
  estrogen receptor 1
  estrogen receptor 2
  eukaryotic translation initiation factor 2B subunit alpha
  eukaryotic translation initiation factor 2B subunit delta
  EWS RNA binding protein 1
  ezrin
  family with sequence similarity 98 member B
  Fas associated via death domain
  F-box and WD repeat domain containing 7
  flap structure-specific endonuclease 1
  GDP dissociation inhibitor 1
  heat shock protein family B (small) member 1
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A3
  histidine triad nucleotide binding protein 1
  histone deacetylase 6
  homocysteine inducible ER protein with ubiquitin like domain 1
  hydroxysteroid 17-beta dehydrogenase 10
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inositol monophosphatase 1
  inositol monophosphatase 2
  inositol-3-phosphate synthase 1
  insulin like growth factor 2 mRNA binding protein 1
  junction plakoglobin
  leucine rich repeat kinase 2
  lysine acetyltransferase 2B
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase 8
  moesin
  MYC proto-oncogene, bHLH transcription factor
  myristoylated alanine rich protein kinase C substrate
  NEDD4 like E3 ubiquitin protein ligase
  neurotrophic receptor tyrosine kinase 1
  p21 (RAC1) activated kinase 1
  phosphofructokinase, muscle
  phosphofructokinase, platelet
  pirin
  plastin 3
  pleckstrin homology domain containing A4
  proliferating cell nuclear antigen
  proline rich coiled-coil 2B
  proteasome 26S subunit, non-ATPase 10
  protection of telomeres 1
  protein disulfide isomerase family A member 3
  PTEN induced kinase 1
  RAB11A, member RAS oncogene family
  Rac family small GTPase 1
  Rac family small GTPase 2
  Rac family small GTPase 3
  radixin
  RAP1A, member of RAS oncogene family
  ras homolog family member H
  RecQ like helicase 4
  Rho GDP dissociation inhibitor alpha
  Sad1 and UNC84 domain containing 2
  SH3 domain containing GRB2 like 3, endophilin A3
  sirtuin 2
  sirtuin 7
  small ubiquitin like modifier 3
  small ubiquitin like modifier 4
  ST3 beta-galactoside alpha-2,3-sialyltransferase 4
  stomatin
  succinate dehydrogenase complex subunit C
  telomeric repeat binding factor 1
  TERF1 interacting nuclear factor 2
  thioredoxin
  TNF receptor superfamily member 10b
  TNF receptor superfamily member 1A
  tripartite motif containing 13
  twinfilin actin binding protein 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 R2
  ubiquitin C-terminal hydrolase L3
  ubiquitin fold modifier 1
  vav guanine nucleotide exchange factor 1
  WD repeat domain 26

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.