BID, BH3 interacting domain death agonist

BID, BH3 interacting domain death agonist

• This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jan 2020]

• Gene Synonyms (BH3-interacting domain death agonist, BH3 interacting domain death agonist Si6 isoform, BID isoform ES(1b), BID isoform L(2), BID isoform Si6, Human BID coding sequence, apoptic death agonist, desmocollin type 4, p22 BID, FP497,)
• NCBI Gene ID: 637
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55957
  UNIPROT ID#>>A8ASI8
  UNIPROT ID#>>B2ZP79
  UNIPROT ID#>>B3KT21
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BH3 interacting domain death agonist interacts with:

• adenosylhomocysteinase like 1
  ADP ribosylation factor like GTPase 6 interacting protein 6
  BAG cochaperone 3
  basonuclin 1
  BH3 interacting domain death agonist
  calpain 1
  calpain 2
  casein kinase 1 alpha 1
  casein kinase 1 epsilon
  casein kinase 2 alpha 1
  casein kinase 2 alpha 2
  casein kinase 2 beta
  caspase 1
  caspase 10
  caspase 2
  caspase 3
  caspase 8
  caveolin 1
  cell division cycle 5 like
  chromobox 5
  chromosome 1 open reading frame 198
  collapsin response mediator protein 1
  crooked neck pre-mRNA splicing factor 1
  dimethylarginine dimethylaminohydrolase 2
  DNA damage inducible transcript 4 like
  ergosterol biosynthesis 28 homolog
  ezrin
  Fas associated via death domain
  Fc fragment of IgG receptor IIa
  fibrillin 3
  forkhead box K1
  GIPC PDZ domain containing family member 1
  glutamine amidotransferase like class 1 domain containing 3A
  glyceraldehyde-3-phosphate dehydrogenase
  granzyme B
  guanylate binding protein 2
  histidine triad nucleotide binding protein 1
  hydroxysteroid 17-beta dehydrogenase 10
  itchy E3 ubiquitin protein ligase
  MCL1 apoptosis regulator, BCL2 family member
  mercaptopyruvate sulfurtransferase
  methyl-CpG binding domain protein 5
  mitogen-activated protein kinase 8
  moesin
  Mov10 RISC complex RNA helicase
  nuclear RNA export factor 1
  nucleoporin 93
  phosphofurin acidic cluster sorting protein 2
  pleckstrin homology and RUN domain containing M1
  pleckstrin homology domain containing A4
  RAB11 family interacting protein 5
  REL proto-oncogene, NF-kB subunit
  replication protein A1
  replication protein A2
  RNA binding motif protein 48
  sequestosome 1
  SET domain bifurcated histone lysine methyltransferase 1
  small ubiquitin like modifier 1
  TLE family member 1, transcriptional corepressor
  TNF receptor superfamily member 10b
  TNF receptor superfamily member 1A
  tripartite motif containing 25
  tubulin beta 2B class IIb
  tubulin folding cofactor A
  tumor protein, translationally-controlled 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquilin 2
  valosin containing protein
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.