RHOH, ras homolog family member H

RHOH, ras homolog family member H

• The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

• Gene Synonyms (rho-related GTP-binding protein RhoH, GTP-binding protein TTF, TTF, translocation three four, ras homolog gene family, member H, ARHH, TTF,)
• NCBI Gene ID: 399
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6ICP4
  UNIPROT ID#>>Q15669
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ras homolog family member H interacts with:

• BTG3 associated nuclear protein
  catenin delta 1
  cyclin H
  family with sequence similarity 90 member A1
  GDP dissociation inhibitor 1
  integrin subunit beta 1 binding protein 1
  IQ motif and ubiquitin domain containing
  KN motif and ankyrin repeat domains 2
  LCK proto-oncogene, Src family tyrosine kinase
  ligand dependent nuclear receptor interacting factor 1
  metallo-beta-lactamase domain containing 1
  metaxin 2
  pleckstrin homology domain containing A7
  potassium voltage-gated channel subfamily H member 2
  ripply transcriptional repressor 1
  sodium channel modifier 1
  sortilin related receptor 1
  sulfite oxidase
  transcription factor 19
  transforming growth factor beta receptor 1
  UTP14A small subunit processome component
  X-prolyl aminopeptidase 1
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger and BTB domain containing 33

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.