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Product Availability Update

Promega Manufacturing and Delivery Systems continue to be fully operational during the COVID-19 outbreak. Our teams are in regular contact with suppliers and distributors worldwide to manage inventory of raw materials to ensure continued availability. Due to rigorous operations processes and dedicated teams, Promega is addressing both demands for COVID-19 diagnostic tools and reliable delivery of all Promega products as quickly as possible. As this global situation evolves, we will take all steps necessary to continue providing our customers with high quality products, information and support. Learn more about COVID-19 products and support here.

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Sequencing Grade Modified Trypsin, Frozen, Product Information

Instructions for Use of Product(s)

Literature # 9PIV5113

Trypsin specifically hydrolyzes peptide bonds at the carboxyl side of lysine and arginine residues. Unmodified trypsin is subject to auto-proteolysis, generating fragments that can interfere with protein sequencing of HPLC peptide analysis. In addition, auto-proteolysis can result in the generation of pseudotrypsin, which has been shown to exhibit chymotrypsin-like specificity. Promega Sequencing Grade Modified Trypsin is porcine trypsin modified by reductive methylation, rendering it resistant to proteolytic digestion. In enzymatic stability tests, modified trypsin was found to retain greater than two times the activity of unmodified trypsin.

Revised 4/18.