PTPRC, protein tyrosine phosphatase receptor type C

PTPRC, protein tyrosine phosphatase receptor type C

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

• Gene Synonyms (receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200,)
• NCBI Gene ID: 5788
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MT22
  UNIPROT ID#>>X6R433
  UNIPROT ID#>>M9MML4
  UNIPROT ID#>>P08575
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase receptor type C interacts with:

• acidic nuclear phosphoprotein 32 family member A
  autophagy related 16 like 1
  C-X-C motif chemokine receptor 4
  ezrin
  F-box protein 6
  glucosidase II alpha subunit
  LSM1 homolog, mRNA degradation associated
  PPFIA binding protein 2
  protein tyrosine phosphatase receptor type C
  protein tyrosine phosphatase receptor type C associated protein
  PTPRF interacting protein alpha 1
  RAS p21 protein activator 1
  ring finger protein 11
  semaphorin 4D
  signaling lymphocytic activation molecule family member 1
  src kinase associated phosphoprotein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  tyrosine kinase 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like with PHD and ring finger domains 2
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.