ELOA, elongin A

ELOA, elongin A

• This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (elongin-A, RNA polymerase II transcription factor SIII subunit A1, elongin 110 kDa subunit, transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A), transcription elongation factor B alpha subunit, transcription elongation factor B polypeptide 3, transcription elongation factor B subunit 3, SIII, SIII p110, TCEB3, TCEB3A,)
• NCBI Gene ID: 6924
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14241
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

elongin A interacts with:

• ankyrin repeat and SOCS box containing 9
  anoctamin 7
  ANTXR cell adhesion molecule 2
  axin 2
  BTB domain and CNC homolog 2
  cell division cycle 14B
  centrobin, centriole duplication and spindle assembly protein
  centrosomal protein 57 like 1
  centrosomal protein 70
  cerebellar degeneration related protein 2 like
  chibby family member 2
  chromatin assembly factor 1 subunit A
  coiled-coil domain containing 57
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 3
  cullin 5
  cyclin dependent kinase 12
  ecotropic viral integration site 5
  family with sequence similarity 9 member B
  FCH and mu domain containing endocytic adaptor 1
  FMR1 autosomal homolog 1
  germ cell-less 1, spermatogenesis associated
  golgin A6 family member A
  GRIP1 associated protein 1
  H3 clustered histone 1
  homeobox and leucine zipper encoding
  hyaluronan binding protein 4
  janus kinase and microtubule interacting protein 2
  kelch like family member 2
  keratin 40
  keratin associated protein 10-3
  KN motif and ankyrin repeat domains 2
  KxDL motif containing 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine zipper tumor suppressor 1
  leucine zipper tumor suppressor 2
  lysine acetyltransferase 8
  mediator complex subunit 21
  mediator complex subunit 26
  midline 2
  neurexin 1
  NFKB inhibitor delta
  ninein like
  nuclear assembly factor 1 ribonucleoprotein
  nucleus accumbens associated 1
  period circadian regulator 2
  pescadillo ribosomal biogenesis factor 1
  pleckstrin homology domain containing A4
  polo like kinase 4
  PR/SET domain 6
  protein arginine methyltransferase 5
  PTPRF interacting protein alpha 1
  rabaptin, RAB GTPase binding effector protein 1
  RAD54 homolog B
  Rho GTPase activating protein 26
  RNA exonuclease 1 homolog
  RPGRIP1 like
  SERPINE1 mRNA binding protein 1
  signal regulatory protein alpha
  solute carrier family 13 member 2
  sperm antigen with calponin homology and coiled-coil domains 1 like
  suppressor of cytokine signaling 1
  TNFAIP3 interacting protein 1
  TNFAIP3 interacting protein 2
  tripartite motif containing 54
  tumor protein p53 binding protein 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  zinc finger protein 792

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.