POLE, DNA polymerase epsilon, catalytic subunit

POLE, DNA polymerase epsilon, catalytic subunit

• This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

• Gene Synonyms (DNA polymerase epsilon catalytic subunit A, 3'-5' exodeoxyribonuclease, DNA polymerase II subunit A, DNA polymerase epsilon catalytic subunit protein, polymerase (DNA directed), epsilon, catalytic subunit, polymerase (DNA) epsilon, catalytic subunit, CRCS12, FILS, IMAGEI, POLE1,)
• NCBI Gene ID: 5426
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q07864
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA polymerase epsilon, catalytic subunit interacts with:

• abhydrolase domain containing 16A, phospholipase
  ariadne RBR E3 ubiquitin protein ligase 1
  bMERB domain containing 1
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2A
  cytosolic iron-sulfur assembly component 2B
  dickkopf like acrosomal protein 1
  DNA polymerase delta 4, accessory subunit
  DNA polymerase epsilon 2, accessory subunit
  DNA polymerase epsilon 3, accessory subunit
  DNA polymerase epsilon 4, accessory subunit
  DNA polymerase epsilon, catalytic subunit
  DNA primase subunit 1
  DNA topoisomerase II binding protein 1
  DnaJ heat shock protein family (Hsp40) member C7
  DTW domain containing 2
  dual specificity phosphatase 15
  dual specificity phosphatase 26
  egl-9 family hypoxia inducible factor 3
  F-box and WD repeat domain containing 11
  F-box protein 38
  forkhead box B1
  forkhead box Q1
  GINS complex subunit 4
  leucine rich repeat containing 46
  limb development membrane protein 1 like
  listerin E3 ubiquitin protein ligase 1
  LY6/PLAUR domain containing 4
  mediator complex subunit 23
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myotubularin related protein 4
  peroxisomal biogenesis factor 19
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 4
  protein tyrosine phosphatase non-receptor type 14
  RAD17 checkpoint clamp loader component
  receptor interacting serine/threonine kinase 4
  ribosomal protein L28
  ribosomal protein L36a
  RNA polymerase II subunit B
  serine/threonine kinase 19
  sirtuin 7
  small RNA binding exonuclease protection factor La
  SNW domain containing 1
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  timeless circadian regulator
  TRAF interacting protein
  transformed mouse 3T3 cell double minute 2
  trans-golgi network protein 2
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tripartite motif containing 28
  vir like m6A methyltransferase associated
  X-ray repair cross complementing 5
  zinc finger B-box domain containing
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.