POLE2, DNA polymerase epsilon 2, accessory subunit

POLE2, DNA polymerase epsilon 2, accessory subunit

• DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]

• Gene Synonyms (DNA polymerase epsilon subunit 2, DNA polymerase II subunit 2, DNA polymerase epsilon subunit B, polymerase (DNA directed), epsilon 2 (p59 subunit), polymerase (DNA directed), epsilon 2, accessory subunit, polymerase (DNA) epsilon 2, accessory subunit, DPE2,)
• NCBI Gene ID: 5427
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56282
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA polymerase epsilon 2, accessory subunit interacts with:

• ADP ribosylation factor like GTPase 4C
  BAR/IMD domain containing adaptor protein 2 like 2
  bMERB domain containing 1
  chromosome 6 open reading frame 141
  cytochrome P450 family 4 subfamily F member 12
  DNA polymerase delta 4, accessory subunit
  DNA polymerase epsilon 3, accessory subunit
  DNA polymerase epsilon 4, accessory subunit
  DnaJ heat shock protein family (Hsp40) member C7
  ergosterol biosynthesis 28 homolog
  exosome component 4
  kallikrein related peptidase 11
  kallikrein related peptidase 5
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat containing 46
  lysine acetyltransferase 5
  microtubule associated protein RP/EB family member 1
  myotubularin related protein 4
  nuclear RNA export factor 1
  peroxisomal biogenesis factor 19
  pleckstrin homology domain containing A4
  polycomb group ring finger 1
  RAD17 checkpoint clamp loader component
  REL proto-oncogene, NF-kB subunit
  ribosomal protein L28
  serine peptidase inhibitor, Kunitz type 2
  Sin3A associated protein 18
  small RNA binding exonuclease protection factor La
  sorbin and SH3 domain containing 3
  sorting nexin family member 21
  T-box transcription factor 15
  terminal nucleotidyltransferase 5A
  timeless circadian regulator
  TIMELESS interacting protein
  TLE family member 1, transcriptional corepressor
  transcription activation suppressor
  transcription factor AP-4
  tripartite motif containing 27
  ubiquilin 2
  ubiquitin like modifier activating enzyme 2
  zinc finger and BTB domain containing 21
  zinc finger BED-type containing 1
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 620

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.