HOMER3, homer scaffold protein 3

HOMER3, homer scaffold protein 3

• This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

• Gene Synonyms (homer protein homolog 3, Homer, neuronal immediate early gene, 3, homer homolog 3, homer scaffolding protein 3, HOMER-3, VESL3,)
• NCBI Gene ID: 9454
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NSC5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

homer scaffold protein 3 interacts with:

• ABI family member 3
  abl interactor 1
  abl interactor 2
  ADP ribosylation factor like GTPase 13B
  breast carcinoma amplified sequence 2
  CDC16 cell division cycle 16
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 192
  centrosomal protein 44
  chromosome 1 open reading frame 116
  chromosome 4 open reading frame 17
  coiled-coil domain containing 120
  coiled-coil domain containing 141
  coiled-coil domain containing 187
  c-src tyrosine kinase
  CWF19 like cell cycle control factor 2
  cytoplasmic FMR1 interacting protein 2
  DNA polymerase gamma 2, accessory subunit
  DNA polymerase iota
  dynein light chain LC8-type 2
  EF-hand domain containing 1
  ELL associated factor 1
  eukaryotic translation initiation factor 4E family member 2
  FAM161 centrosomal protein B
  family with sequence similarity 90 member A1
  F-box protein 28
  FRY like transcription coactivator
  gametogenetin
  glutamate receptor, metabotropic 5
  heterogeneous nuclear ribonucleoprotein L like
  homer scaffold protein 1
  homer scaffold protein 2
  homer scaffold protein 3
  homer scaffolding protein 1
  homer scaffolding protein 2
  inhibitor of CDK, cyclin A1 interacting protein 1
  intraflagellar transport 57
  keratin associated protein 19-7
  KN motif and ankyrin repeat domains 2
  KN motif and ankyrin repeat domains 4
  leucine rich repeat containing 7
  ligand of numb-protein X 1
  LSM family member 14B
  lysine demethylase 1A
  Mdm1 nuclear protein
  membrane palmitoylated protein 5
  MIA SH3 domain ER export factor 3
  MSS51 mitochondrial translational activator
  NCK associated protein 1
  nebulette
  NHL repeat containing 2
  N-terminal glutamine amidase 1
  nucleoporin 54
  paired box 6
  palladin, cytoskeletal associated protein
  PATJ crumbs cell polarity complex component
  phospholipase A and acyltransferase 5
  POM121 transmembrane nucleoporin
  proline rich 35
  protein phosphatase 1 regulatory subunit 18
  protein phosphatase 1 regulatory subunit 32
  psoriasis susceptibility 1 candidate 2
  RNA binding motif protein 14
  RNA binding motif protein 22
  SLAIN motif family member 1
  SNW domain containing 1
  sodium channel modifier 1
  SRY-box transcription factor 17
  stabilizer of axonemal microtubules 1
  submaxillary gland androgen regulated protein 3B
  TBC1 domain family member 22B
  TOX high mobility group box family member 2
  WASP family member 2
  WW domain binding protein 2
  zinc finger and BTB domain containing 4
  zinc finger protein 414
  zinc finger protein 655

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.