KDM6A, lysine demethylase 6A

KDM6A, lysine demethylase 6A

• This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

• Gene Synonyms (lysine-specific demethylase 6A, [histone H3]-trimethyl-L-lysine(27) demethylase 6A, bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)), histone demethylase UTX, lysine (K)-specific demethylase 6A, ubiquitously transcribed tetratricopeptide repeat protein X-linked, ubiquitously-transcribed TPR gene on the X chromosome, KABUK2, UTX, bA386N14.2,)
• NCBI Gene ID: 7403
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86TD1
  UNIPROT ID#>>B7ZKN5
  UNIPROT ID#>>E1U0S6
  UNIPROT ID#>>B7ZKN6
  UNIPROT ID#>>B4E0L8
  UNIPROT ID#>>Q59HG3
  UNIPROT ID#>>O15550
  UNIPROT ID#>>B7ZKN1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine demethylase 6A interacts with:

• ASH2 like, histone lysine methyltransferase complex subunit
  ASXL transcriptional regulator 1
  ASXL transcriptional regulator 2
  ASXL transcriptional regulator 3
  BRCA1 associated protein 1
  bromodomain containing 4
  dpy-30 histone methyltransferase complex regulatory subunit
  forkhead box K1
  H3 clustered histone 1
  H3 clustered histone 14
  H3.4 histone
  H4 clustered histone 1
  inhibitor of growth family member 3
  lysine demethylase 5C
  lysine demethylase 6A
  lysine methyltransferase 2C
  lysine methyltransferase 2D
  MAF bZIP transcription factor A
  MAF bZIP transcription factor B
  metadherin
  NEDD4 binding protein 2
  nuclear receptor coactivator 6
  O-linked N-acetylglucosamine (GlcNAc) transferase
  PAX interacting protein 1
  pleckstrin homology domain containing A4
  proline and serine rich 1
  protein phosphatase 6 regulatory subunit 3
  Rho GTPase activating protein 22
  SUZ12 polycomb repressive complex 2 subunit
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 82
  zinc finger protein 281

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.