RTN3, reticulon 3

RTN3, reticulon 3

• This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

• Gene Synonyms (ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon-3, ASY interacting protein, NSP-like protein 2, NSP-like protein II, homolog of ASY protein, neuroendocrine-specific protein-like 2, neuroendocrine-specific protein-like II,)
• NCBI Gene ID: 10313
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5C4
  UNIPROT ID#>>O95197
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

reticulon 3 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  atlastin GTPase 3
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase
  family with sequence similarity 160 member A2
  G protein-coupled receptor 152
  limb development membrane protein 1 like
  microtubule interacting and trafficking domain containing 1
  NDRG family member 4
  phosphoribosyl transferase domain containing 1
  pleckstrin homology and FYVE domain containing 2
  pleckstrin homology domain containing A4
  protein phosphatase 2 regulatory subunit B''gamma
  regulator of microtubule dynamics 2
  reticulon 3
  reticulon 4
  ring finger protein 31
  SAC1 like phosphatidylinositide phosphatase
  solute carrier family 30 member 8
  synoviolin 1
  tectonic family member 2
  tectonic family member 3
  zinc finger protein 391

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.