BCL2, BCL2 apoptosis regulator

BCL2, BCL2 apoptosis regulator

• This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

• Gene Synonyms (apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, protein phosphatase 1, regulatory subunit 50, Bcl-2, PPP1R50,)
• NCBI Gene ID: 596
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R2B3
  UNIPROT ID#>>P10415
  UNIPROT ID#>>A0A024R2C4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 apoptosis regulator interacts with:

• apoptosis and caspase activation inhibitor
  autophagy and beclin 1 regulator 1
  autophagy related 12
  B cell receptor associated protein 31
  BAG cochaperone 3
  BAG cochaperone 4
  BCL2 apoptosis regulator
  BCL2 associated transcription factor 1
  BCL2 binding component 3
  BCL2 interacting killer
  BCL2 interacting protein 1
  BCL2 interacting protein 2
  BCL2 interacting protein 3
  BCL2 interacting protein 3 like
  BCL2 interacting protein like
  BCL2 like 1
  BCL2 like 10
  BCL2 like 11
  BCL2 like 12
  BCL2 like 14
  Bcl2 modifying factor
  BCL2-associated X protein
  BCL2-like 11 (apoptosis facilitator)
  beclin 1
  beclin 1, autophagy related
  BH3 interacting domain death agonist
  BH3-like motif containing, cell death inducer
  bifunctional apoptosis regulator
  BLK proto-oncogene, Src family tyrosine kinase
  BRCA1 DNA repair associated
  calpain 2
  carnitine palmitoyltransferase 1A
  caspase 2
  caspase 3
  caspase 8
  CDGSH iron sulfur domain 2
  component of inhibitor of nuclear factor kappa B kinase complex
  crystallin alpha B
  cullin 4A
  cyclin dependent kinase 1
  cyclin dependent kinase 2
  cyclin dependent kinase 4
  cytochrome c, somatic
  dynein light chain LC8-type 1
  Fas apoptotic inhibitory molecule 2
  FKBP prolyl isomerase 8
  GTPase, IMAP family member 5
  harakiri, BCL2 interacting protein
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 1A
  heterogeneous nuclear ribonucleoprotein D
  HRas proto-oncogene, GTPase
  hypoxia inducible factor 1 subunit alpha
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  inositol 1,4,5-trisphosphate receptor type 1
  inositol 1,4,5-trisphosphate receptor type 3
  insulin receptor substrate 1
  insulin receptor substrate 2
  integral membrane protein 2B
  intelectin 1
  kelch like ECH associated protein 1
  KRAS proto-oncogene, GTPase
  leucine rich pentatricopeptide repeat containing
  MDM4 regulator of p53
  methionine adenosyltransferase 2A
  mex-3 RNA binding family member D
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 11
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  modulator of apoptosis 1
  MYC proto-oncogene, bHLH transcription factor
  NLR family pyrin domain containing 1
  N-myristoyltransferase 2
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 4 group A member 1
  parkin RBR E3 ubiquitin protein ligase
  paxillin
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase D
  peroxisome proliferator activated receptor alpha
  phorbol-12-myristate-13-acetate-induced protein 1
  PML nuclear body scaffold
  presenilin 1
  presenilin 2
  protein kinase C alpha
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase, membrane associated tyrosine/threonine 1
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit gamma
  RAD9 checkpoint clamp component A
  Raf-1 proto-oncogene, serine/threonine kinase
  Ras homolog, mTORC1 binding
  RAS related
  reticulon 3
  reticulon 4
  ring finger protein 183
  septin 4
  sequestosome 1
  serpin family B member 8
  sphingolipid transporter 1 (putative)
  splicing factor 1
  superoxide dismutase 1
  survival of motor neuron 1, telomeric
  survival of motor neuron 2, centromeric
  TNFAIP3 interacting protein 2
  translocase of outer mitochondrial membrane 20
  transmembrane BAX inhibitor motif containing 6
  tumor protein p53
  tumor protein p53 binding protein 2
  tumor protein p53 regulated apoptosis inducing protein 1
  ubiquitin conjugating enzyme E2 I
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.