BLK, BLK proto-oncogene, Src family tyrosine kinase

BLK, BLK proto-oncogene, Src family tyrosine kinase

• This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

• Gene Synonyms (tyrosine-protein kinase Blk, B lymphoid tyrosine kinase, BLK nonreceptor tyrosine kinase, b lymphocyte kinase, p55-Blk, MODY11,)
• NCBI Gene ID: 640
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9PJX5
  UNIPROT ID#>>Q05D26
  UNIPROT ID#>>P51451
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BLK proto-oncogene, Src family tyrosine kinase interacts with:

• alpha-1,4-N-acetylglucosaminyltransferase
  amyloid beta precursor protein binding family B member 3
  ankyrin repeat domain 54
  ATP synthase inhibitory factor subunit 1
  ATP synthase membrane subunit DAPIT
  ATP synthase membrane subunit f
  ATP synthase membrane subunit g
  ATP synthase peripheral stalk subunit d
  BCAS2 pre-mRNA processing factor
  breast carcinoma amplified sequence 2
  calcium/calmodulin dependent protein kinase I
  Cbl proto-oncogene
  CD79a molecule
  CD79b molecule
  coiled-coil domain containing 33
  CRK like proto-oncogene, adaptor protein
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cytohesin 1 interacting protein
  embryonal Fyn-associated substrate
  epidermal growth factor receptor
  ER degradation enhancing alpha-mannosidase like protein 2
  erb-b2 receptor tyrosine kinase 2
  eukaryotic translation elongation factor 1 epsilon 1
  eukaryotic translation elongation factor 2
  family with sequence similarity 217 member B
  F-box protein 7
  Fc fragment of IgG receptor IIa
  Fc fragment of IgG receptor IIb
  flagellum associated containing coiled-coil domains 1
  FMR1 autosomal homolog 1
  FMR1 autosomal homolog 2
  G protein subunit gamma 12
  glyceraldehyde-3-phosphate dehydrogenase
  glycine receptor alpha 2
  glyoxylate reductase 1 homolog
  growth factor receptor bound protein 10
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 beta family member 1
  heat shock transcription factor 2 binding protein
  HEXIM P-TEFb complex subunit 1
  IKAROS family zinc finger 3
  janus kinase and microtubule interacting protein 1
  La ribonucleoprotein 7, transcriptional regulator
  midline 2
  myelin basic protein
  paxillin
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 2
  prohibitin 2
  protein interacting with PRKCA 1
  ribonuclease A family member 3
  secretoglobin family 1A member 1
  SH2 domain containing 1B
  signal transducer and activator of transcription 3
  signal transducing adaptor family member 2
  single stranded DNA binding protein 3
  small nuclear ribonucleoprotein D1 polypeptide
  solute carrier family 30 member 4
  src kinase associated phosphoprotein 2
  Src like adaptor
  SUMO specific peptidase 1
  suppressor of cytokine signaling 3
  synaptonemal complex protein 3
  tyrosyl-DNA phosphodiesterase 2
  ubiquitin protein ligase E3A
  Y-box binding protein 3
  zinc finger and BTB domain containing 32
  zinc finger and BTB domain containing 42
  zinc finger and BTB domain containing 8A
  zinc finger matrin-type 1
  zinc finger protein 774

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.