CD59, CD59 molecule (CD59 blood group)

CD59, CD59 molecule (CD59 blood group)

• This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD59 glycoprotein, 1F5 antigen, 20 kDa homologous restriction factor, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), CD59 blood group antigen, CD59 molecule, complement regulatory protein, Ly-6-like protein, MEM43 antigen, T cell-activating protein, human leukocyte antigen MIC11, lymphocytic antigen CD59/MEM43, membrane attack complex (MAC) inhibition factor, membrane attack complex inhibition factor, membrane inhibitor of reactive lysis, protectin, surface anitgen recognized by monoclonal antibody 16.3A5, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20,)
• NCBI Gene ID: 966
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13987
  UNIPROT ID#>>Q6FHM9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD59 molecule (CD59 blood group) interacts with:

• ATP binding cassette subfamily E member 1
  ATPase H+ transporting accessory protein 2
  CF transmembrane conductance regulator
  coronin, actin binding protein 1C
  DExD-box helicase 39B
  drebrin 1
  epidermal growth factor receptor
  estrogen receptor 2
  family with sequence similarity 209 member A
  filamin A
  filamin, beta
  G protein subunit alpha i3
  galactokinase 2
  golgi transport 1B
  growth factor receptor bound protein 2
  histone deacetylase 4
  huntingtin
  insulin like growth factor binding protein 1
  mediator complex subunit 9
  microtubule associated protein RP/EB family member 1
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  natural cytotoxicity triggering receptor 1
  natural cytotoxicity triggering receptor 3
  phosphatidylethanolamine binding protein 1
  poly(A) specific ribonuclease subunit PAN2
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  RAD18 E3 ubiquitin protein ligase
  ring finger protein 138
  ring finger protein 4
  ring finger protein 6
  sequestosome 1
  SMAD family member 4
  solute carrier family 13 member 1
  solute carrier family 6 member 8
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRY-box transcription factor 2
  synaptopodin
  testis expressed 101
  translocase of outer mitochondrial membrane 5
  transmembrane serine protease 11B
  tropomodulin 3
  tropomyosin 1, alpha
  tubulointerstitial nephritis antigen like 1
  ubiquitin conjugating enzyme E2 A
  voltage dependent anion channel 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.