ALDH4A1, aldehyde dehydrogenase 4 family member A1

ALDH4A1, aldehyde dehydrogenase 4 family member A1

• This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]

• Gene Synonyms (delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, L-glutamate gamma-semialdehyde dehydrogenase, P5C dehydrogenase, aldehyde dehydrogenase family 4 member A1, epididymis secretory sperm binding protein, mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase, ALDH4, P5CD, P5CDh,)
• NCBI Gene ID: 8659
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30038
  UNIPROT ID#>>A0A024RAD8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aldehyde dehydrogenase 4 family member A1 interacts with:

• aldehyde dehydrogenase 4 family member A1
  chloride intracellular channel 4
  destrin, actin depolymerizing factor
  glutaredoxin 5
  lactate dehydrogenase A like 6A
  lactate dehydrogenase A like 6B
  leucine aminopeptidase 3
  lysophospholipase like 1
  methionine sulfoxide reductase B2
  mitochondrial rRNA methyltransferase 1
  myotrophin
  peptidase, mitochondrial processing subunit alpha
  peptidyl-tRNA hydrolase domain containing 1
  phosphoglucomutase 2
  transmembrane protein 184A
  tripartite motif containing 28
  tRNA methyltransferase 61B

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