PMPCA, peptidase, mitochondrial processing subunit alpha

PMPCA, peptidase, mitochondrial processing subunit alpha

• The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016]

• Gene Synonyms (Alpha-MPP, CLA1, CPD3, INPP5E, P-55, SCAR2, mitochondrial-processing peptidase subunit alpha, Cerebellar ataxia-1, cerebellar ataxia 1 (autosomal recessive), inactive zinc metalloprotease alpha, inositol polyphosphate-5-phosphatase, 72 kD, mitochondrial matrix processing protease, alpha subunit, peptidase, mitochondrial processing alpha subunit,)
• NCBI Gene ID: 23203
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q10713
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peptidase, mitochondrial processing subunit alpha interacts with:

• abhydrolase domain containing 10, depalmitoylase
  acid phosphatase 6, lysophosphatidic
  apolipoprotein O like
  bolA family member 1
  CDGSH iron sulfur domain 3
  chloride intracellular channel 4
  chorionic gonadotropin subunit beta 2
  chromosome 15 open reading frame 48
  clustered mitochondria homolog
  CMT1A duplicated region transcript 15
  coenzyme Q10A
  coenzyme Q6, monooxygenase
  coenzyme Q8A
  coenzyme Q8B
  coenzyme Q9
  coiled-coil domain containing 69
  coiled-coil-helix-coiled-coil-helix domain containing 1
  coiled-coil-helix-coiled-coil-helix domain containing 2
  cytochrome c oxidase assembly factor 7 (putative)
  dual specificity phosphatase 26
  ETHE1 persulfide dioxygenase
  FAD dependent oxidoreductase domain containing 1
  formation of mitochondrial complex V assembly factor 1 homolog
  glutaredoxin 5
  growth hormone inducible transmembrane protein
  haloacid dehalogenase like hydrolase domain containing 5
  lactamase beta 2
  leucine aminopeptidase 3
  LYR motif containing 1
  LYR motif containing 4
  MAGI family member, X-linked
  matrix AAA peptidase interacting protein 1
  methylcrotonoyl-CoA carboxylase 2
  methyltransferase like 14
  mitochondrial ribosome associated GTPase 2
  mitochondrial rRNA methyltransferase 1
  mitochondrial rRNA methyltransferase 3
  mitochondrial transcription rescue factor 1
  myotrophin
  NAD(P)HX epimerase
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  NADH:ubiquinone oxidoreductase complex assembly factor 8
  nudix hydrolase 8
  odontogenesis associated phosphoprotein
  p21 (RAC1) activated kinase 5
  pleckstrin homology domain containing A4
  polyribonucleotide nucleotidyltransferase 1
  protein O-glucosyltransferase 3
  protein phosphatase, Mg2+/Mn2+ dependent 1K
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RCC1 like
  RNA pseudouridine synthase domain containing 2
  spermatogenesis associated 20
  SPRY domain containing 4
  succinate dehydrogenase complex assembly factor 3
  succinate dehydrogenase complex assembly factor 4
  succinyl-CoA:glutarate-CoA transferase
  testis expressed 101
  thioredoxin domain containing 12
  tRNA methyltransferase 61B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.