PNPT1, polyribonucleotide nucleotidyltransferase 1

PNPT1, polyribonucleotide nucleotidyltransferase 1

• The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]

• Gene Synonyms (polyribonucleotide nucleotidyltransferase 1, mitochondrial, 3'-5' RNA exonuclease OLD35, PNPase 1, PNPase old-35, polynucleotide phosphorylase 1, polynucleotide phosphorylase-like protein, COXPD13, DFNB70, OLD35, PNPASE, old-35,)
• NCBI Gene ID: 87178
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TCS8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

polyribonucleotide nucleotidyltransferase 1 interacts with:

• glutamyl-tRNA amidotransferase subunit C
  serpin family A member 12

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