SUPT4H1, SPT4 homolog, DSIF elongation factor subunit

SUPT4H1, SPT4 homolog, DSIF elongation factor subunit

• This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

• Gene Synonyms (transcription elongation factor SPT4, DRB sensitivity-inducing factor 14 kDa subunit, DSIF p14, small hSpt4 subunit, suppressor of Ty 4 homolog 1, SPT4, SPT4H, SUPT4H, Supt4a,)
• NCBI Gene ID: 6827
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P63272
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SPT4 homolog, DSIF elongation factor subunit interacts with:

• decapping enzyme, scavenger
  docking protein 4
  eukaryotic translation initiation factor 3 subunit D
  HIV-1 Tat specific factor 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat kinase 2
  ligand dependent nuclear receptor interacting factor 1
  malignant fibrous histiocytoma amplified sequence 1
  neuronal vesicle trafficking associated 2
  nuclear RNA export factor 1
  p21 (RAC1) activated kinase 5
  PDZ and LIM domain 1
  regulation of nuclear pre-mRNA domain containing 1B
  RNA guanylyltransferase and 5'-phosphatase
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  suppressor of cytokine signaling 2
  translation machinery associated 16 homolog
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  zinc finger MYND-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.