PRIM2, DNA primase subunit 2

PRIM2, DNA primase subunit 2

• This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]

• Gene Synonyms (DNA primase large subunit, DNA primase 58 kDa subunit, primase (DNA) subunit 2, primase, DNA, polypeptide 2 (58kDa), PRIM2A, p58,)
• NCBI Gene ID: 5558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49643
  UNIPROT ID#>>A0A024RD43
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA primase subunit 2 interacts with:

• 5'-3' exoribonuclease 2
  BAG cochaperone 6
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2B
  DDB1 and CUL4 associated factor 10
  DNA polymerase alpha 2, accessory subunit
  DNA primase subunit 2
  elongation factor Tu GTP binding domain containing 2
  endoplasmic reticulum protein 44
  glucose-fructose oxidoreductase domain containing 1
  kelch like family member 20
  LEO1 homolog, Paf1/RNA polymerase II complex component
  lysine demethylase 1A
  MAD2 mitotic arrest deficient-like 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  neuroligin 4 Y-linked
  peptidase M20 domain containing 2
  phosphoribosyl pyrophosphate synthetase 2
  pleckstrin homology domain containing A4
  RecQ like helicase 4
  regulator of G protein signaling 20
  reversion inducing cysteine rich protein with kazal motifs
  ribonucleic acid export 1
  ribosomal protein L35
  ring finger protein 31
  small nuclear RNA activating complex polypeptide 1
  STN1 subunit of CST complex
  suppressor of variegation 3-9 homolog 1
  transcription activation suppressor
  transformer 2 beta homolog
  tripartite motif containing 14
  tripartite motif containing 28
  tumor protein, translationally-controlled 1
  ubiquitin like modifier activating enzyme 2
  ubiquitin specific peptidase 37
  zinc finger HIT-type containing 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.