SCAP, SREBF chaperone

SCAP, SREBF chaperone

• This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

• Gene Synonyms (sterol regulatory element-binding protein cleavage-activating protein, SREBP cleavage-activating protein,)
• NCBI Gene ID: 22937
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z6H0
  UNIPROT ID#>>Q12770
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SREBF chaperone interacts with:

• ATPase Na+/K+ transporting family member beta 4
  butyrophilin like 8
  golgi membrane protein 1
  inositol-pentakisphosphate 2-kinase
  insulin induced gene 2
  limb development membrane protein 1 like
  mucolipin 3
  N-acetylated alpha-linked acidic dipeptidase like 2
  OTU deubiquitinase with linear linkage specificity like
  pleckstrin homology domain containing A4
  regulatory associated protein of MTOR complex 1
  SREBF chaperone
  zinc and ring finger 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.