ARFGEF2, ADP ribosylation factor guanine nucleotide exchange factor 2

ARFGEF2, ADP ribosylation factor guanine nucleotide exchange factor 2

• ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

• Gene Synonyms (BIG2, PVNH2, dJ1164I10.1, brefeldin A-inhibited guanine nucleotide-exchange protein 2, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), brefeldin A-inhibited GEP 2,)
• NCBI Gene ID: 10564
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y6D5
  UNIPROT ID#>>Q86TH5
  UNIPROT ID#>>Q59FR3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADP ribosylation factor guanine nucleotide exchange factor 2 interacts with:

• ADP ribosylation factor guanine nucleotide exchange factor 1
  ankyrin repeat and MYND domain containing 2
  CD244 molecule
  cell division cycle 73
  chondroitin sulfate N-acetylgalactosaminyltransferase 1
  dystrobrevin binding protein 1
  exocyst complex component 7
  itchy, E3 ubiquitin protein ligase
  lysosomal associated membrane protein 3
  melanocortin 2 receptor accessory protein 2
  MYC binding protein
  PAF1 homolog, Paf1/RNA polymerase II complex component
  patatin like phospholipase domain containing 2
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 40 homolog A
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  SIGLEC family like 1
  SNW domain containing 1
  sperm acrosome associated 1
  stromal cell derived factor 4
  TMEM9 domain family member B
  trans-golgi network protein 2
  transmembrane protein 171
  vasorin
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.