ERLIN2, ER lipid raft associated 2

ERLIN2, ER lipid raft associated 2

• This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

• Gene Synonyms (erlin-2, SPFH domain family, member 2, endoplasmic reticulum lipid raft-associated protein 2, epididymis secretory sperm binding protein, spastic paraplegia 18 (autosomal dominant), stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2, C8orf2, Erlin-2, NET32, SPFH2, SPG18,)
• NCBI Gene ID: 11160
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94905
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ER lipid raft associated 2 interacts with:

• adhesion molecule with Ig like domain 1
  aph-1 homolog A, gamma-secretase subunit
  arylsulfatase family member K
  bone morphogenetic protein receptor, type 1A
  CD109 molecule
  centrosomal protein 128
  coiled-coil domain containing 47
  complement component 1, q subcomponent binding protein
  derlin 1
  ER degradation enhancing alpha-mannosidase like protein 3
  ER lipid raft associated 1
  eukaryotic translation elongation factor 1 alpha 1
  Fas associated factor family member 2
  F-box protein 6
  FKBP prolyl isomerase 14
  golgi transport 1B
  heterogeneous nuclear ribonucleoprotein U like 2
  histone deacetylase 11
  inositol 1,4,5-trisphosphate receptor 1
  kelch-like 21
  kinectin 1
  limb development membrane protein 1 like
  mitochondrial calcium uniporter
  MMS19 homolog, cytosolic iron-sulfur assembly component
  nicastrin
  pleckstrin homology domain containing A4
  presenilin enhancer, gamma-secretase subunit
  protein phosphatase 6 regulatory subunit 3
  RAB5C, member RAS oncogene family
  RAN binding protein 2
  ras homolog family member T1
  regulator of microtubule dynamics 3
  RIC3 acetylcholine receptor chaperone
  ring finger protein 139
  ring finger protein 170
  ring finger protein 170
  ring finger protein 185
  RPGRIP1 like
  sodium channel and clathrin linker 1
  solute carrier family 15 member 3
  SREBF chaperone
  SRP receptor subunit beta
  synoviolin 1
  tectonic family member 1
  translocase of inner mitochondrial membrane 50
  transmembrane and ubiquitin like domain containing 1
  transmembrane and ubiquitin like domain containing 2
  transmembrane p24 trafficking protein 10
  transmembrane p24 trafficking protein 2
  transmembrane protein 259
  transmembrane protein 41B
  transmembrane protein 63B
  transmembrane protein 67
  tubulin alpha 8
  tubulin beta class I
  UBA domain containing 2
  UFM1 specific ligase 1
  unc-93 homolog B1, TLR signaling regulator
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.