CD86, CD86 molecule

CD86, CD86 molecule

• This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

• Gene Synonyms (T-lymphocyte activation antigen CD86, B-lymphocyte activation antigen B7-2, BU63, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CTLA-4 counter-receptor B7.2, FUN-1, B7-2, B7.2, B70, CD28LG2, LAB72,)
• NCBI Gene ID: 942
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42081
  UNIPROT ID#>>A0A0X9R4E0
  UNIPROT ID#>>A8K632
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD86 molecule interacts with:

• CD86 molecule
  cytotoxic T-lymphocyte associated protein 4
  endothelin converting enzyme 2
  membrane associated ring-CH-type finger 1
  membrane associated ring-CH-type finger 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.