- Gene Overview
- Interaction Network
- Sequence Verification
MARCHF8, membrane associated ring-CH-type finger 8
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MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
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Gene Synonyms (E3 ubiquitin-protein ligase MARCHF8, E3 ubiquitin-protein ligase MARCH8, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8, RING-type E3 ubiquitin transferase MARCHF8, c-mir, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), membrane associated ring finger 8, membrane-associated RING finger protein 8, membrane-associated RING-CH protein VIII, membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase, CMIR, MARCH-VIII, MARCH8, MIR, RNF178, c-MIR,)
- NCBI Gene ID:
220972
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>A0A024R7U2
UNIPROT ID#>>Q5T0T0
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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membrane associated ring-CH-type finger 8 interacts with:
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