CD3E, CD3e molecule

CD3E, CD3e molecule

• The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

• Gene Synonyms (T-cell surface glycoprotein CD3 epsilon chain, CD3-epsilon, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, IMD18, T3E, TCRE,)
• NCBI Gene ID: 916
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P07766
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD3e molecule interacts with:

• ADAM metallopeptidase domain 33
  CD247 molecule
  CD38 molecule
  CD3g molecule
  CD79b molecule
  C-terminal Src kinase
  DNA topoisomerase II beta
  EPS8 like 1
  family with sequence similarity 241 member B
  GH3 domain containing
  glycoprotein Ib platelet subunit beta
  ITPRIP like 1
  Janus kinase 3
  LCK proto-oncogene, Src family tyrosine kinase
  leucyl and cystinyl aminopeptidase
  linker for activation of T cells
  major histocompatibility complex, class I, A
  mucin 15, cell surface associated
  NCK adaptor protein 1
  NCK adaptor protein 2
  nucleolin
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  protein kinase, membrane associated tyrosine/threonine 1
  protein tyrosine phosphatase non-receptor type 22
  RNA polymerase I subunit G
  SHC adaptor protein 1
  spleen associated tyrosine kinase
  syntrophin alpha 1
  T cell receptor associated transmembrane adaptor 1
  TM2 domain containing 3
  unc-119 lipid binding chaperone
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger protein like 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.