CD3G, CD3g molecule

CD3G, CD3g molecule

• The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

• Gene Synonyms (T-cell surface glycoprotein CD3 gamma chain, CD3g antigen, gamma polypeptide (TiT3 complex), CD3g molecule, epsilon (CD3-TCR complex), CD3g molecule, gamma (CD3-TCR complex), T-cell antigen receptor complex, gamma subunit of T3, T-cell receptor T3 gamma chain, CD3-GAMMA, IMD17, T3G,)
• NCBI Gene ID: 917
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09693
  UNIPROT ID#>>B0YIY5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CD3g molecule interacts with:

• epithelial membrane protein 1
  FYN proto-oncogene, Src family tyrosine kinase
  growth factor receptor bound protein 2
  kinectin 1
  linker for activation of T cells
  mal, T cell differentiation protein
  nuclear receptor subfamily 3 group C member 1
  peripheral myelin protein 22
  phosphoinositide-3-kinase regulatory subunit 1
  SHC adaptor protein 1
  transmembrane protein 19
  transmembrane protein 203
  transmembrane protein 262
  transmembrane protein 54
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.