RPS6KA4, ribosomal protein S6 kinase A4

RPS6KA4, ribosomal protein S6 kinase A4

• This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

• Gene Synonyms (ribosomal protein S6 kinase alpha-4, 90 kDa ribosomal protein S6 kinase 4, mitogen- and stress-activated protein kinase 2, nuclear mitogen- and stress-activated protein kinase 2, ribosomal protein S6 kinase, 90kDa, polypeptide 4, ribosomal protein kinase B, MSK2, RSK-B, S6K-alpha-4,)
• NCBI Gene ID: 8986
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0PJF8
  UNIPROT ID#>>E9PJN1
  UNIPROT ID#>>O75676
  UNIPROT ID#>>B4DPV1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribosomal protein S6 kinase A4 interacts with:

• cell division cycle 37, HSP90 cochaperone
  cytochrome P450 family 4 subfamily F member 12
  DEAD-box helicase 42
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  kelch domain containing 3
  mannan binding lectin serine peptidase 2
  mesoderm development LRP chaperone
  mitogen-activated protein kinase kinase kinase kinase 1
  myosin light chain kinase 2
  pleckstrin homology domain containing A4
  ribosomal protein S6 kinase A4
  SH3 domain containing kinase binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.