MYOM1, myomesin 1

MYOM1, myomesin 1

• The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (myomesin-1, 190 kDa connectin-associated protein, 190 kDa titin-associated protein, EH-myomesin, myomesin (M-protein) 1 (190kD), myomesin 1 (skelemin) 185kDa, myomesin 1 variant 1, myomesin 1, 185kDa, myomesin family member 1, SKELEMIN,)
• NCBI Gene ID: 8736
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52179
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myomesin 1 interacts with:

• keratin associated protein 1-1
  keratin associated protein 5-7
  microtubule associated scaffold protein 2
  myomesin 1
  phosphodiesterase 4D interacting protein
  protein phosphatase 1 regulatory subunit 16A
  tuftelin interacting protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.