TLE3, TLE family member 3, transcriptional corepressor

TLE3, TLE family member 3, transcriptional corepressor

• This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

• Gene Synonyms (transducin-like enhancer protein 3, enhancer of split groucho 3, enhancer of split groucho-like protein 3, transducin like enhancer of split 3, transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila), transducin-like enhancer of split 3 short isoform, transducin-like enhancer of split 3, homolog of Drosophila E(sp1), ESG, ESG3, GRG3, HsT18976,)
• NCBI Gene ID: 7090
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6PRX3
  UNIPROT ID#>>B3KUA2
  UNIPROT ID#>>Q04726
  UNIPROT ID#>>H0YL70
  UNIPROT ID#>>F5H7D6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TLE family member 3, transcriptional corepressor interacts with:

• activator of transcription and developmental regulator AUTS2
  adenosylhomocysteinase like 1
  Aly/REF export factor
  armadillo repeat containing 8
  calcium homeostasis endoplasmic reticulum protein
  chaperonin containing Tcp1, subunit 3 (gamma)
  COPI coat complex subunit gamma 1
  COPI coat complex subunit zeta 1
  cullin 4B
  F-box protein 7
  forkhead box B1
  forkhead box G1
  forkhead box Q1
  H2A clustered histone 1
  H3 clustered histone 1
  H4 clustered histone 1
  histone H4 transcription factor
  keratin associated protein 15-1
  LIM homeobox 6
  nemo like kinase
  N-myc downstream regulated 1
  quinolinate phosphoribosyltransferase
  ripply transcriptional repressor 1
  ripply transcriptional repressor 2
  SEC24 homolog A, COPII coat complex component
  signal transducing adaptor molecule
  SIX homeobox 2
  SIX homeobox 4
  StAR related lipid transfer domain containing 7
  sulfiredoxin 1
  TBC1 domain family member 4
  T-box transcription factor 20
  titin
  TLE family member 3, transcriptional corepressor
  TLE family member 4, transcriptional corepressor
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3 component n-recognin 5
  valosin containing protein
  VENT homeobox
  vir like m6A methyltransferase associated
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.