ZEB1, zinc finger E-box binding homeobox 1

ZEB1, zinc finger E-box binding homeobox 1

• This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

• Gene Synonyms (zinc finger E-box-binding homeobox 1, delta-crystallin enhancer binding factor 1, negative regulator of IL2, posterior polymorphous corneal dystrophy 3, transcription factor 8 (represses interleukin 2 expression), zinc finger homeodomain enhancer-binding protein, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A,)
• NCBI Gene ID: 6935
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2RBI8
  UNIPROT ID#>>B4DGU2
  UNIPROT ID#>>P37275
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

zinc finger E-box binding homeobox 1 interacts with:

• COP9 signalosome subunit 5
  DDB1 and CUL4 associated factor 15
  DR1 associated protein 1
  lysine acetyltransferase 5
  M-phase phosphoprotein 8
  poly(A) specific ribonuclease subunit PAN2
  sirtuin 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  tumor protein p53 binding protein 1
  ubiquitin C-terminal hydrolase L3
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin specific peptidase 10
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 26
  ubiquitin specific peptidase 29
  ubiquitin specific peptidase 42
  ubiquitin specific peptidase 51
  ubiquitin specific peptidase 53
  ubiquitin specific peptidase 54
  ubiquitin specific peptidase 7
  valosin containing protein interacting protein 1
  zinc finger MIZ-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.