TBX3, T-box transcription factor 3

TBX3, T-box transcription factor 3

• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (T-box transcription factor TBX3, T-box 3, T-box protein 3, bladder cancer related protein XHL, TBX3-ISO, UMS, XHL,)
• NCBI Gene ID: 6926
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RBQ4
  UNIPROT ID#>>O15119
  UNIPROT ID#>>A0A024RBL6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

T-box transcription factor 3 interacts with:

• cell division cycle associated 5
  decapping mRNA 1A
  DnaJ heat shock protein family (Hsp40) member C11
  eukaryotic translation initiation factor 4A3
  H4 clustered histone 1
  heterogeneous nuclear ribonucleoprotein L like
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  kinesin family member 21A
  kinesin family member 21B
  N(alpha)-acetyltransferase 15, NatA auxiliary subunit
  nuclear FMR1 interacting protein 2
  pleckstrin homology and FYVE domain containing 2
  poly(A) binding protein cytoplasmic 4
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  RNA binding motif protein X-linked
  signal regulatory protein alpha
  SMAD family member 3
  T-box transcription factor 3
  thymopoietin
  toll interacting protein
  ubiquitin specific peptidase 10
  UFM1 specific peptidase 1 (inactive)
  X-ray repair cross complementing 5
  zinc finger protein 34

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.