TBX5, T-box transcription factor 5

TBX5, T-box transcription factor 5

• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (T-box transcription factor TBX5, T-box 5, T-box protein 5, HOS,)
• NCBI Gene ID: 6910
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99593
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

T-box transcription factor 5 interacts with:

• BAR/IMD domain containing adaptor protein 2
  F-box protein 25
  lysine acetyltransferase 5
  lysine demethylase 6A
  WW domain containing transcription regulator 1
  zinc finger MYND-type containing 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.