STXBP2, syntaxin binding protein 2

STXBP2, syntaxin binding protein 2

• This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]

• Gene Synonyms (syntaxin-binding protein 2, protein unc-18 homolog B, unc-18B, FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122,)
• NCBI Gene ID: 6813
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53GF4
  UNIPROT ID#>>Q15833
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

syntaxin binding protein 2 interacts with:

• BAG cochaperone 2
  coiled-coil domain containing 8
  DEAD-box helicase 20
  FA complementation group I
  gem nuclear organelle associated protein 2
  gem nuclear organelle associated protein 4
  nuclear receptor subfamily 2 group C member 2
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 10
  RAB11 family interacting protein 5
  SMAD family member 3
  solute carrier family 25 member 41
  spermatogenesis associated 24
  SSU72 homolog, RNA polymerase II CTD phosphatase
  synaptosome associated protein 23
  syntaxin 11
  syntaxin 19
  syntaxin binding protein 3
  tripartite motif containing 28
  tubulin, gamma 1
  tumor suppressor candidate 3
  vesicle associated membrane protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.