SLC12A2, solute carrier family 12 member 2

SLC12A2, solute carrier family 12 member 2

• The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

• Gene Synonyms (solute carrier family 12 member 2, basolateral Na-K-Cl symporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, protein phosphatase 1, regulatory subunit 141, solute carrier family 12 (sodium/potassium/chloride transporter), member 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 2, BSC, BSC2, NKCC1, PPP1R141,)
• NCBI Gene ID: 6558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53ZR1
  UNIPROT ID#>>P55011
  UNIPROT ID#>>B7ZM24
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 12 member 2 interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  Bet1 golgi vesicular membrane trafficking protein
  bone morphogenetic protein receptor, type 1A
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  CDKN2A interacting protein
  centromere protein E
  coiled-coil domain containing 8
  complement component 1, q subcomponent binding protein
  copper metabolism domain containing 1
  CTD small phosphatase like
  cullin 7
  family with sequence similarity 189 member A2
  G protein subunit gamma 12
  galectin 9C
  limb development membrane protein 1 like
  mucolipin 3
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase with linear linkage specificity like
  oxidative stress responsive kinase 1
  pleckstrin homology domain containing A4
  serine/threonine kinase 39
  solute carrier family 12 member 2
  tectonic family member 3
  trans-golgi network protein 2
  transmembrane p24 trafficking protein 6
  transmembrane protein 17
  transmembrane protein 216
  vir like m6A methyltransferase associated
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.