SBDS, SBDS ribosome maturation factor

SBDS, SBDS ribosome maturation factor

• This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]

• Gene Synonyms (ribosome maturation protein SBDS, SBDS, ribosome assembly guanine nucleotide exchange factor, CGI-97, SDS, SWDS,)
• NCBI Gene ID: 51119
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5I7
  UNIPROT ID#>>Q9Y3A5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SBDS ribosome maturation factor interacts with:

• ACD shelterin complex subunit and telomerase recruitment factor
  acyl-CoA thioesterase 13
  alanyl-tRNA synthetase domain containing 1
  autophagy related 16 like 1
  chromosome alignment maintaining phosphoprotein 1
  elongation factor like GTPase 1
  fermitin family member 1
  kelch like family member 6
  mitochondrial ribosomal protein L53
  M-phase specific PLK1 interacting protein
  pleckstrin homology domain containing A4
  PTGES3L-AARSD1 readthrough
  SAP domain containing ribonucleoprotein
  seryl-tRNA synthetase 2, mitochondrial
  SRA stem-loop interacting RNA binding protein
  SRP receptor subunit beta
  TERF2 interacting protein
  TNFAIP3 interacting protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.