BACE1, beta-secretase 1

BACE1, beta-secretase 1

• This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

• Gene Synonyms (beta-secretase 1, APP beta-secretase, asp 2, aspartyl protease 2, beta-secretase 1 precursor variant 1, beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, beta-site amyloid beta A4 precursor protein-cleaving enzyme, memapsin-2, membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2, ASP2, BACE, HSPC104,)
• NCBI Gene ID: 23621
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56817
  UNIPROT ID#>>B7Z3Z4
  UNIPROT ID#>>A0A024R3D7
  UNIPROT ID#>>B7Z3K2
  UNIPROT ID#>>A0A024R3F9
  UNIPROT ID#>>A0A024R3E8
  UNIPROT ID#>>A0A024R3D5
  UNIPROT ID#>>Q5W9H2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-secretase 1 interacts with:

• brain protein I3
  cytidine/uridine monophosphate kinase 1
  F-box protein 2
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  integral membrane protein 2C
  proprotein convertase subtilisin/kexin type 9
  secretoglobin family 1D member 4
  thioredoxin related transmembrane protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.