ATP6V0A2, ATPase H+ transporting V0 subunit a2

ATP6V0A2, ATPase H+ transporting V0 subunit a2

• The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

• Gene Synonyms (V-type proton ATPase 116 kDa subunit a2, V-type proton ATPase 116 kDa subunit a, A2V-ATPase, ATPase, H+ transporting, lysosomal V0 subunit a2, V-ATPase 116 kDa subunit a2, lysosomal H(+)-transporting ATPase V0 subunit a2, regeneration and tolerance factor, v-ATPase 116 kDa, v-type proton ATPase 116 kDa subunit a, vacuolar proton translocating ATPase 116 kDa subunit a, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS,)
• NCBI Gene ID: 23545
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y487
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATPase H+ transporting V0 subunit a2 interacts with:

• ATPase H+ transporting V0 subunit d2
  ATPase H+ transporting V1 subunit D
  ATPase phospholipid transporting 11C
  coiled-coil domain containing 115
  KIAA2013
  MARCKS like 1
  OTU deubiquitinase with linear linkage specificity like
  peptidyl-tRNA hydrolase 2
  protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
  ribosomal protein L10 like
  serine incorporator 2
  SPRY domain containing 7
  tectonic family member 3
  transmembrane and coiled-coil domain family 3
  transmembrane protein 185A
  transmembrane protein 199
  transmembrane protein 63B
  tRNA-yW synthesizing protein 1 homolog
  vacuolar ATPase assembly factor VMA21
  zinc and ring finger 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.