FCAR, Fc fragment of IgA receptor

FCAR, Fc fragment of IgA receptor

• This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CD89, CTB-61M7.2, FcalphaRI, immunoglobulin alpha Fc receptor, FCAR variant 14, Fc alpha receptor, Fc fragment of IgA, receptor for,)
• NCBI Gene ID: 2204
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4N4
  UNIPROT ID#>>A0A024R4R4
  UNIPROT ID#>>P24071
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fc fragment of IgA receptor interacts with:

• EFR3 homolog B
  Fc fragment of IgA receptor
  Fc fragment of IgE receptor Ig
  Fc fragment of IgG receptor Ia
  histidine ammonia-lyase
  LYN proto-oncogene, Src family tyrosine kinase
  osteoclast associated Ig-like receptor
  paired immunoglobin like type 2 receptor alpha
  protein phosphatase 2 catalytic subunit alpha

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.