DNASE2, deoxyribonuclease 2, lysosomal

DNASE2, deoxyribonuclease 2, lysosomal

• This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]

• Gene Synonyms (deoxyribonuclease-2-alpha, DNase II alpha, DNase II, lysosomal, R31240_2, acid DNase, deoxyribonuclease II alpha, deoxyribonuclease II, lysosomal, lysosomal DNase II, DNASE2A, DNL, DNL2,)
• NCBI Gene ID: 1777
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00115
  UNIPROT ID#>>A0A024R7F4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

deoxyribonuclease 2, lysosomal interacts with:

• 5'-3' exoribonuclease 1
  DnaJ heat shock protein family (Hsp40) member B11
  F-box protein 6
  OPA1 mitochondrial dynamin like GTPase
  ribonucleotide reductase catalytic subunit M1
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  tripartite motif containing 25
  valosin containing protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.