MALT1, MALT1 paracaspase

MALT1, MALT1 paracaspase

• This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018]

• Gene Synonyms (IMD12, MLT, MLT1, PCASP1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT1 protease, caspase-like protein, mucosa associated lymphoid tissue lymphoma translocation gene 1, paracaspase-1,)
• NCBI Gene ID: 10892
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UDY8
  UNIPROT ID#>>A8K5S1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MALT1 paracaspase interacts with:

• caspase recruitment domain family member 11
  caspase recruitment domain family member 14
  COP9 signalosome subunit 5
  diablo IAP-binding mitochondrial protein
  fem-1 homolog A
  fem-1 homolog C
  HECT domain E3 ubiquitin protein ligase 3
  lysine demethylase 1A
  MALT1 paracaspase
  pleckstrin homology domain containing A4
  protein arginine methyltransferase 6
  ring finger protein 31
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.