SIVA1, SIVA1 apoptosis inducing factor

SIVA1, SIVA1 apoptosis inducing factor

• This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]

• Gene Synonyms (CD27BP, SIVA, Siva-1, Siva-2, apoptosis regulatory protein Siva, CD27-binding (Siva) protein,)
• NCBI Gene ID: 10572
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15304
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SIVA1 apoptosis inducing factor interacts with:

• brain expressed X-linked 3
  cation channel sperm associated 1
  chromosome 2 open reading frame 68
  egl-9 family hypoxia inducible factor 3
  forkhead box P3
  inhibitor of growth family member 3
  keratin associated protein 26-1
  NEDD4 like E3 ubiquitin protein ligase
  N-terminal glutamine amidase 1
  peptidase M20 domain containing 2
  proliferating cell nuclear antigen
  RAD18 E3 ubiquitin protein ligase
  ras homolog family member U
  RNA polymerase II subunit M
  single stranded DNA binding protein 3
  transcription factor AP-2 delta
  zinc finger protein 446

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.