BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B

BUB1B, BUB1 mitotic checkpoint serine/threonine kinase B

• This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

• Gene Synonyms (mitotic checkpoint serine/threonine-protein kinase BUB1 beta, BUB1B, mitotic checkpoint serine/threonine kinase, MAD3/BUB1-related protein kinase, budding uninhibited by benzimidazoles 1 homolog beta, mitotic checkpoint kinase MAD3L, BUB1beta, BUBR1, Bub1A, MAD3L, MVA1, SSK1, hBUBR1,)
• NCBI Gene ID: 701
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60566
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BUB1 mitotic checkpoint serine/threonine kinase B interacts with:

• adaptor related protein complex 3 subunit beta 1
  adaptor related protein complex 4 subunit beta 1
  ajuba LIM protein
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 10
  anaphase promoting complex subunit 13
  anaphase promoting complex subunit 16
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 4
  anaphase promoting complex subunit 7
  anaphase-promoting complex subunit 5
  aurora kinase B
  BAG cochaperone 2
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BUB1 mitotic checkpoint serine/threonine kinase B
  BUB1, mitotic checkpoint serine/threonine kinase
  BUB1B, mitotic checkpoint serine/threonine kinase
  BUB3 mitotic checkpoint protein
  CD14 molecule
  CDC16 cell division cycle 16
  CDC23 cell division cycle 23
  cell division cycle 16
  cell division cycle 20
  cell division cycle 20
  cell division cycle 23
  cell division cycle 26
  cell division cycle 27
  cell division cycle 5 like
  centromere protein E
  centromere protein K
  centromere protein M
  centrosomal protein 295
  centrosomal protein 63
  ceramide kinase
  chaperonin containing TCP1 subunit 2
  COMM domain containing 4
  cyclin A2
  death domain associated protein
  DSN1 component of MIS12 kinetochore complex
  dual specificity tyrosine phosphorylation regulated kinase 1A
  dynamin binding protein
  dynein cytoplasmic 1 light intermediate chain 1
  egl-9 family hypoxia inducible factor 3
  eukaryotic translation elongation factor 2
  exosome component 2
  exportin 1
  F-box and WD repeat domain containing 7
  F-box protein 6
  F-box protein 7
  fizzy and cell division cycle 20 related 1
  glucosidase II alpha subunit
  heat shock protein family A (Hsp70) member 8
  heat shock protein family B (small) member 1
  heat shock protein family H (Hsp110) member 1
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  inner membrane protein, mitochondrial
  kinetochore scaffold 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  lysine acetyltransferase 2B
  MAD2 mitotic arrest deficient-like 1
  MAD2L1 binding protein
  MAX interactor 1, dimerization protein
  MDM2 proto-oncogene
  mediator complex subunit 4
  MIS12 kinetochore complex component
  MIS12 kinetochore complex component
  mitogen-activated protein kinase kinase kinase 4
  mitotic arrest deficient 2 like 1
  Mtr4 exosome RNA helicase
  N-alpha-acetyltransferase 50, NatE catalytic subunit
  NDC80 kinetochore complex component
  NDC80 kinetochore complex component
  NFKB activating protein
  NIMA related kinase 2
  NSL1 component of MIS12 kinetochore complex
  nucleolar protein 8
  NUF2 component of NDC80 kinetochore complex
  pellino E3 ubiquitin protein ligase 1
  pleckstrin homology domain containing A4
  PNMA family member 2
  polo like kinase 1
  polo like kinase 3
  polyamine modulated factor 1
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 6
  proteasome 20S subunit beta 5
  proteasome 26S subunit, non-ATPase 6
  protein kinase C substrate 80K-H
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 4 regulatory subunit 3A
  PTTG1 regulator of sister chromatid separation, securin
  pyrimidinergic receptor P2Y6
  receptor interacting serine/threonine kinase 3
  ribonucleic acid export 1
  ribosomal protein L39
  SCY1 like pseudokinase 1
  shugoshin 1
  small ubiquitin like modifier 1
  SNW domain containing 1
  spindle and kinetochore associated complex subunit 3
  suppressor of cytokine signaling 2
  synuclein gamma
  thyroid hormone receptor interactor 13
  tripartite motif containing 33
  tRNA-yW synthesizing protein 3 homolog
  tubulin beta class I
  tumor protein p73
  ubiquitin conjugating enzyme E2 C
  ubiquitin protein ligase E3 component n-recognin 5
  UDP-glucose pyrophosphorylase 2
  WD repeat domain 61
  zinc finger C3H1-type containing
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.