BCL6, BCL6 transcription repressor

BCL6, BCL6 transcription repressor

• The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

• Gene Synonyms (B-cell lymphoma 6 protein, B cell CLL/lymphoma 6, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL-5, BCL-6, cys-his2 zinc finger transcription factor, lymphoma-associated zinc finger gene on chromosome 3, protein LAZ-3, zinc finger and BTB domain-containing protein 27, zinc finger protein 51, zinc finger transcription factor BCL6S, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51,)
• NCBI Gene ID: 604
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B5B0A5
  UNIPROT ID#>>P41182
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL6 transcription repressor interacts with:

• activating transcription factor 7
  ankyrin repeat domain 53
  arrestin domain containing 3
  aryl hydrocarbon receptor interacting protein
  aryl hydrocarbon receptor nuclear translocator 2
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  BAF chromatin remodeling complex subunit BCL11A
  basic leucine zipper nuclear factor 1
  BCL6 corepressor
  BCL6 transcription repressor
  BCL6B transcription repressor
  BTB domain and CNC homolog 2
  calcium binding protein 4
  calcium voltage-gated channel subunit alpha1 A
  catenin beta 1
  C-C motif chemokine ligand 3
  CCR4-NOT transcription complex subunit 2
  Cdc42 guanine nucleotide exchange factor 9
  cereblon
  CFAP97 domain containing 1
  chromodomain helicase DNA binding protein 3
  chromosome 4 open reading frame 45
  chromosome 7 open reading frame 31
  chromosome 9 open reading frame 24
  cilia and flagella associated protein 161
  CREB binding protein
  C-terminal binding protein 1
  CUB and Sushi multiple domains 1
  cullin 3
  cutC copper transporter
  cyclin D2
  cyclin dependent kinase 19
  cyclin dependent kinase 8
  DEAD-box helicase 6
  dishevelled segment polarity protein 2
  drosha ribonuclease III
  dynein axonemal heavy chain 9
  E1A binding protein p300
  E2F transcription factor 3
  EBF transcription factor 1
  EPH receptor B6
  ERCC excision repair 5, endonuclease
  euchromatic histone lysine methyltransferase 1
  eukaryotic translation initiation factor 2 alpha kinase 3
  eukaryotic translation initiation factor 4E nuclear import factor 1
  F-box protein 11
  forkhead box M1
  GATA binding protein 1
  glutaredoxin 3
  golgin A2
  heat shock protein 90 alpha family class A member 1
  heat shock transcription factor 4
  helicase with zinc finger 2
  heparin binding EGF like growth factor
  histone deacetylase 1
  histone deacetylase 2
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 7
  histone deacetylase 9
  HNF1 homeobox A
  interactor of HORMAD1 1
  interferon regulatory factor 4
  interleukin 32
  isopentenyl-diphosphate delta isomerase 2
  Jun proto-oncogene, AP-1 transcription factor subunit
  JunB proto-oncogene, AP-1 transcription factor subunit
  JunD proto-oncogene, AP-1 transcription factor subunit
  kelch like family member 12
  kelch like family member 20
  keratin associated protein 13-1
  keratin associated protein 13-2
  keratin associated protein 19-1
  kinesin family member 13B
  kinesin family member C3
  LIM zinc finger domain containing 3
  LIM zinc finger domain containing 4
  lipopolysaccharide induced TNF factor
  LSM1 homolog, mRNA degradation associated
  lysine demethylase 2A
  lysine demethylase 2B
  lysine methyltransferase 2B
  lysophosphatidic acid receptor 2
  lysophosphatidic acid receptor 4
  mediator complex subunit 17
  mediator complex subunit 23
  mediator complex subunit 6
  metastasis associated 1 family member 3
  methyl-CpG binding domain protein 3
  microtubule associated scaffold protein 2
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8 interacting protein 3
  MyoD family inhibitor
  NAD(P)HX dehydratase
  NFKB repressing factor
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nucleus accumbens associated 1
  Obg like ATPase 1
  oxysterol binding protein like 1A
  pannexin 3
  PBX homeobox 4
  pellino E3 ubiquitin protein ligase 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peroxisome proliferator activated receptor alpha
  peroxisome proliferator activated receptor delta
  peroxisome proliferator activated receptor gamma
  peroxisome proliferator activator receptor delta
  phosphoinositide kinase, FYVE-type zinc finger containing
  phospholipid phosphatase 3
  PML nuclear body scaffold
  POF1B actin binding protein
  poly(ADP-ribose) polymerase family member 12
  polycomb group ring finger 1
  POU class 2 homeobox 3
  PPARG coactivator 1 alpha
  prefoldin subunit 5
  proteasome 20S subunit beta 4
  protein arginine methyltransferase 5
  protein kinase C epsilon
  protein kinase D3
  protein phosphatase targeting COQ7
  protocadherin 9
  Raf-1 proto-oncogene, serine/threonine kinase
  REL proto-oncogene, NF-kB subunit
  Rho GTPase activating protein 35
  RUNX1 partner transcriptional co-repressor 1
  serine palmitoyltransferase long chain base subunit 2
  siah E3 ubiquitin protein ligase 1
  SIN3 transcription regulator family member A
  sirtuin 1
  smoothened, frizzled class receptor
  Sp1 transcription factor
  Spi-1 proto-oncogene
  SSX family member 2 interacting protein
  SUMO specific peptidase 7
  SUMO1 activating enzyme subunit 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  tektin 4
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor superfamily member 8
  TRAF3 interacting protein 3
  trans-acting transcription factor 1
  tribbles pseudokinase 3
  tuftelin interacting protein 11
  tumor protein p53
  tumor protein p53 binding protein 1
  twist family bHLH transcription factor 1
  ubiquitin C-terminal hydrolase L1
  ubiquitin specific peptidase 7
  UTP6 small subunit processome component
  WD repeat domain 35
  WD repeat domain 83
  WNK lysine deficient protein kinase 4
  Wnt family member 16
  WT1 associated protein
  YY1 transcription factor
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 17
  zinc finger and BTB domain containing 7A
  zinc finger and BTB domain containing 7B
  zinc finger HIT-type containing 1
  zinc finger MYND-type containing 8
  zinc finger protein 443

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.