TNFRSF8, TNF receptor superfamily member 8

TNFRSF8, TNF receptor superfamily member 8

• The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, cytokine receptor CD30, lymphocyte activation antigen CD30, CD30, D1S166E, Ki-1,)
• NCBI Gene ID: 943
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A5D8T4
  UNIPROT ID#>>P28908
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 8 interacts with:

• ATPase H+ transporting V1 subunit D
  biogenesis of lysosomal organelles complex 1 subunit 1
  cell division cycle 6
  centrosomal protein 57
  coiled-coil domain containing 112
  death associated protein kinase 3
  dpy-19 like C-mannosyltransferase 1
  exocyst complex component 1
  four and a half LIM domains 2
  golgi phosphoprotein 3
  golgi phosphoprotein 3 like
  kinesin family member 3A
  N-alpha-acetyltransferase 20, NatB catalytic subunit
  N-alpha-acetyltransferase 25, NatB auxiliary subunit
  NDC1 transmembrane nucleoporin
  Rac GTPase activating protein 1
  spermatogenesis associated serine rich 2
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  TNF receptor associated factor 5
  TNF receptor superfamily member 8
  TNF receptor-associated factor 1
  TNF receptor-associated factor 2
  TNF superfamily member 8
  TRAF interacting protein
  tyrosyl-DNA phosphodiesterase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.