BCL2L2, BCL2 like 2

BCL2L2, BCL2 like 2

• This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (bcl-2-like protein 2, apoptosis regulator BCL-W, protein phosphatase 1, regulatory subunit 51, BCL-W, BCL2-L-2, BCLW, PPP1R51,)
• NCBI Gene ID: 599
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92843
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BCL2 like 2 interacts with:

• ankyrin repeat and sterile alpha motif domain containing 6
  basic helix-loop-helix family member a9
  BCL2 binding component 3
  BCL2 interacting killer
  BCL2 interacting protein 3
  BCL2 interacting protein 5
  BCL2 like 11
  Bcl2 modifying factor
  BCL2-like 11 (apoptosis facilitator)
  BH3 interacting domain death agonist
  cadherin 1
  CD79a molecule
  CDGSH iron sulfur domain 2
  cell death inducing DFFA like effector b
  cell division cycle 25A
  chondrolectin
  chromosome 10 open reading frame 67
  claudin 7
  ELAV like RNA binding protein 1
  endogenous retrovirus group FRD member 1, envelope
  fetal and adult testis expressed 1
  G protein-coupled receptor 151
  G0/G1 switch 2
  glutathione peroxidase 8 (putative)
  golgin, RAB6 interacting
  harakiri, BCL2 interacting protein
  inositol polyphosphate-1-phosphatase
  KASH domain containing 5
  lamin A/C
  leucine rich repeats and IQ motif containing 1
  microsomal glutathione S-transferase 2
  mitogen-activated protein kinase kinase kinase 8
  mucin 1, cell surface associated
  NKAP domain containing 1
  pannexin 1
  parkin RBR E3 ubiquitin protein ligase
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  potassium inwardly rectifying channel subfamily J member 6
  prostate stem cell antigen
  protein arginine N-methyltransferase 6
  protein phosphatase 1 catalytic subunit alpha
  PTEN induced kinase 1
  rhomboid domain containing 2
  S100 calcium binding protein B
  secretion associated Ras related GTPase 1A
  solute carrier family 27 member 2
  solute carrier family 35 member C2
  solute carrier family 35 member E3
  solute carrier family 39 member 2
  solute carrier family 39 member 6
  S-phase kinase associated protein 2
  sphingosine-1-phosphate lyase 1
  stomatin
  sushi domain containing 3
  testis expressed 11
  thioredoxin related transmembrane protein 1
  THO complex 2
  THO complex 7
  transcription factor 4
  transmembrane protein 139
  tryptase alpha/beta 1
  tumor protein p53

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.